[Progress on the treatment of adolescent idiopathic scoliosis].

Adolescent idiopathic scoliosis (AIS) is a common disease with the age of 10 to 18 years, the Cobb angle more than 10 ° on the coronal plane and combined with the rotation of the vertebral body without other organic lesions. The disease can lead to deformity, pain and even damage of cardiopulmonary function, which seriously affects the physical and mental health and quality of life of patients. For mild to moderate AIS patients, regular observation, braces and other conservative treatment methods can effectively delay the progress of scoliosis. For AIS patients whose conservative treatment is ineffective and reaches the surgical threshold, surgery is recommended. Currently, the prevalent surgical method is posterior vertebral body fusion represented by the pedicle screw internal fixation system, which can often achieve good clinical efficacy. In recent years, Physical Therapeutic Scoliosis Specific Exercise (PSSE) has become more and more popular because of its safety and effectiveness. At present, the specific indications for the treatment of AIS patients are gradually improving, the concept and technology of treatment are constantly updated, and the clinical efficacy is constantly improved. This article will start from two aspects of conservative treatment and surgical treatment, mainly describes the commonly used treatment methods in clinical progress and application as well as the problems faced, in order to provide a reference for the selection of clinical treatment.

[Determination of eighteen elements in Serratulae Chinensis Radix by ICP-MS].

OBJECTIVE: To establish a method for the determination of eighteen elements (Be, Al, Cr, Mn, Ni, Cu, As, Se, Mo, Ag, Cd, Sn, Sb, Ba, Dy, Hg, Tl and Pb) in Serratulae Chinensis Radix by inductively coupled plasma-mass spectrography (ICP-MS). METHODS: After microwave digestion, 18 elements in the samples were determined by ICP-MS and the method was validated. RESULTS: A good linearity of calibration curves was obtained, the mean recovery met the analytical requirement. CONCLUSION: This method is simple, accurate and effective. It provides basis for the research of Serratulae Chinensis Radix.

Characterization of phloroglucinol derivatives and diterpenes in Euphorbia ebracteolata Hayata by utilizing ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Euphorbia ebracteolata Hayata (E. ebracteolata) is a Chinese herbal medicine used for the treatment of tumor diseases. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) based chemical profiling approach was established for the rapid separation and characterization on phloroglucinol derivatives and diterpenes in E. ebracteolata. Three phloroglucinol derivatives and nine diterpenes were identified by exact mass measurement and were further confirmed by Ms2 data. In addition, the chemical profiles of six compounds were acquired by reference standards. Furthermore, the fragmentation rules of phloroglucinol derivatives and diterpenes of E. ebracteolata were analyzed, and each chromatographic peak was classified.

[Analysis of coumarins in Fructus Cnidii by HPLC-ESI-MS].

OBJECTIVE: To analyze coumarins in Fructus Cnidii by HPLC-ESI-MS. METHODS: Coumarins in Fructus Cnidii were subjected to HPLC, using Shim-pack CLC-ODS column, methanol-water (70:30) as mobile phase, and 254 nm as DAD wavelength. A quadrupole mass spectrometer was applied to verify the LC elute, operated in the positive ion mode. RESULTS: Three coumarins were determined and the possible structures of seven coumarins were deduced based on the chromatography and MS data. CONCLUSION: The application of this method could be available for the rapid identification of constituents from traditional Chinese medicines.