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Objective:To investigate the therapeutic effect of Postpartum Zhuyu capsule combined with norethisterone in the treatment of menorrhagia and its influence on sex hormone.Methods:From January 2016 to December 2018, 120 patients with irregular menstruation admitted to the First People's Hospital of Jiande were divided into observation group (60 cases) and control group (60 cases) according to the random digital table method.The control group was treated with norethisterone, while the observation group was treated with Postpartum Zhuyu capsule combined with norethisterone.Both two groups began to use drugs on the 5th day of menstruation, and the course of treatment was three menstrual cycles.The therapeutic effect, PBAC, Pittsburgh sleep quality index (PSQI), sex hormone were compared before and after treatment.Results:The total effective rate of the observation group (95.00%) was higher than that of the control group (75.00%) (χ 2=9.412, P<0.05). After treatment, the scores of PBAC [(72.34±10.38)points] and PSQI[(3.65±1.20)points] in the observation group were lower than those in the control group [(87.82±8.90)points and (6.98±1.45)points] ( t=8.770, 13.705, all P<0.05). The serum E 2 level [(221.28±19.87)ng/L] in the observation group after treatment was higher than that in the control group [(135.42±24.71)ng/L], while FSH [(12.39±2.87)IU/L] and LH [(14.68±2.37)IU/L] were lower than those in the control group [(19.83 ± 2.32)IU/L and (39.94±3.24)IU/L], the differences were statistically significant( t=20.975, 15.616, 48.742, all P<0.05). Conclusion:Postpartum Zhuyu capsule combined with norethisterone is effective in the treatment of menorrhagia.It can improve the serum levels of sex hormone, and improve the quality of life of patients.
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Objective:To investigate the effect of estradiol valerate combined with dydrogesterone on prevention of uterine adhesions after abortion and its influence on sex hormone level.Methods:From January 2018 to October 2019, 142 patients who underwent artificial abortion in the First People's Hospital of Jiande were divided into observation group(71 cases) and control group(71 cases) according to the random digital table mathod.The control group was given postoperative treatment to promote uterine contraction and congestion, and the observation group was given estradiol valerate tablets combined with dydrogesterone tablets on the basis of the control group.The course of treatment in both two groups was 3 months.The bleeding time, bleeding volume and menstrual rehydration time, menstrual volume after operation, the change of serum sex hormone level preoperation and postoperative 3 months, and the occurrence of intrauterine adhesions at 12 months after operation were compared between the two groups.Results:The bleeding time[(4.35±0.97)d] and menstrual recovery time[(24.83±1.43)d] in the observation group were shorter than those in the control group[(5.67±1.14)d and (28.79±1.78)d], and the bleeding amount[(42.54±8.97)mL]in the observation group was less than that in the control group[(53.67±6.81)mL], the differences were statistically significant between the two groups( t=7.431, 14.614, 8.327, all P<0.05). The patients with normal amount of menstruation in the observation group (94.37%) was more than that in the control group(81.69%)(χ 2=5.413, P<0.05). The serum E2 level[(167.39±27.84)ng/L] in the observation group was higher than that in the control group[(108.92±21.01)ng/L], while FSH[(17.83±3.27)IU/L] and LH[(28.98±7.63)IU/L] in the observation group were lower than those in the control group[(26.54±4.58)IU/L and (49.83±13.54)IU/L], the differences were statistically significant between the two groups( t=14.126, 13.042, 11.304, all P<0.05). The incidence of intrauterine adhesions in the observation group(2.82%) was lower than that in the control group(14.08%)(χ 2=5.826, P<0.05). Conclusion:Estradiol valerate combined with dydrogesterone has good effect on the prevention of postoperative uterine adhesions, which can effectively reduce the amount of postoperative bleeding, reduce the amount of postoperative uterine adhesions, improve the amount of menstruation and improve the level of sexual hormones of patients.It is worthy of clinical reference.
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Objective To explore the relationship between the ET-1 and the oncogenesis, development of human esophageal cancer. Methods RT-PCR and Western blotting were employed to detect the expression of ET-1 and ETAR in the tissues of esophageal cancer and normal esophageal mucous membrane from 76 esophageal cancer patients admitted by our hospital from March to December in 2002. Results There was positive ET-1 mRNA expression in 82.7% (62/75) of the specimens of esophageal cancer and in 60% (45/75) of normal tissue and the ET-1 mRNA expression had a relation with histological grade, lymph node metastasis and clinical staging of esophageal cancer (P
