CP-25 inhibits Thl7 cell differentiation and improves kidney injury in MRL/lpr lupus mice / 中国药理学通报

Aim: To explore the role of paeoniflorin-6'- O-benzenesulfonate (CP-25) in MRL/lpr mice and the regulating action on Thl7 cell differentiation. Methods MRL/lpr mice were randomly assigned to five groups as follows; model group, CP-25 (20, 40, 80 mg · kg

Stomatal and Photosynthetic Traits Are Associated with Investigating Sodium Chloride Tolerance of Brassica napus L. Cultivars.

The negative effects of salt stress vary among different rapeseed cultivars. In this study, we investigated the sodium chloride tolerance among 10 rapeseed cultivars based on membership function values (MFV) and Euclidean cluster analyses by exposing seedlings to 0, 100, or 200 mM NaCl. The NaCl toxicity significantly reduced growth, biomass, endogenous K+ levels, relative water content and increased electrolyte leakage, soluble sugar levels, proline levels, and antioxidant enzyme activities. SPAD values were highly variable among rapeseed cultivars. We identified three divergent (tolerant, moderately tolerant, and sensitive) groups. We found that Hua6919 and Yunyoushuang2 were the most salt-tolerant cultivars and that Zhongshuang11 and Yangyou9 were the most salt-sensitive cultivars. The rapeseed cultivars were further subjected to photosynthetic gas exchange and anatomical trait analyses. Among the photosynthetic gas exchange and anatomical traits, the stomatal aperture was the most highly correlated with salinity tolerance in rapeseed cultivars and thus, is important for future studies that aim to improve salinity tolerance in rapeseed. Thus, we identified and characterized two salt-tolerant cultivars that will be useful for breeding programs that aim to develop salt-tolerant rapeseed.

Deglutition function assessment combined with physiological indicators for evaluating the time of retention of gastric tube after tracheal stenosis in infants with congenital heart disease / 中国实用护理杂志

Objective To explore the best time for indwelling gastric tube after tracheal stenosis in infants with congenital heart disease, so as to shorten the indwelling time and relieve the pain of children with tracheal tube. Methods A total of 50 infants with congenital heart disease combined with tracheal stenosis were divided into observation group (26 cases) and control group (24 cases) by the admission order. The observation group accepted swallowing function evaluation combined with physiological indicators to determine the timing of removal of indwelling gastric tube while the control group just conventionally evaluating swallowing function. Results The ICU retention time and total hospitalization days was (4.35 ± 0.94), (23.15 ± 4.92) d in the observation group, and (6.27 ± 1.42), (27.42 ± 6.43) d in the control group, and the difference between the two groups was statistically significant (Z=5.589, 2.621, P<0.05). The extubation time was (2.85 ± 0.23), (4.50 ± 0.27) days in the observation group and the control group, and the difference was statistically significant (χ2= 15.595, P<0.01). Conclusions Deglutition function assessment combined with physiological indicators for evaluating the time of retention of gastric tube after tracheal stenosis in infants with congenital heart disease could be more effective to reduce the occurrence of secondary intubation and postoperative complications,shorten the course of the disease, improve infants comfort level,promote postoperative recovery.