Isolated sulfite oxidase deficiency.

BACKGROUND: Sulfite oxidase deficiency is an uncommon metabolic disease. Only few cases of its isolated form have been reported in the literature. CASE PRESENTATION: We report a case of severe neonatal onset. A newborn baby of 41 weeks gestational age, weighted at birth of 3240 grams and had an Apgar score of 6-10-10. Fifty-three hours after being born, the baby started with seizures that were refractory to antiepileptic treatment. Brain function was monitored using a-EEG. Laboratory and imaging tests were performed. All of them were consistent with sulfite oxidase deficiency. The diagnosis was confirmed by genetic testing. CONCLUSIONS: We highlight the importance of this disease as part of the differential diagnosis of seizures during the neonatal period, as well as the importance of the therapeutic support based on dietary restrictions. It's also remarkable the possibility of prenatal diagnosis by quantifying enzyme activity and it's also possible carrying out DNA mutational analysis.

Psychological effects of Tai Chi Chuan.

This article reviews the scientific studies which have been carried out at the international level on the psychological benefits that Tai Chi Chuan (TCC) brings to those who practice it. It analyzes the framework in which the research was performed, the real benefits that this activity achieves and their causes. The present article brings a new analytical perspective to the reviews carried out to date in regard to classifying and analyzing the psychological variables involved in the practice of TCC and offers a homogeneous framework within which to develop research in this field based on the model proposed by Spirduso et al. (2005).

Blend uniformity analysis: validation and in-process testing. Technical Report No. 25. PDA (Parenteral Drug association).

One of the most challenging problems confronting oral solid dosage form manufacturers today is the difficulty in applying scientifically valid methods to blend uniformity validation. The Wolin decision in U.S. v. Barr Laboratories caused the FDA to reexamine and modify its policies on blend uniformity and sampling techniques. The resulting policies are predicated on the assumption that current technology provides a means to consistently collect minute representative samples from much larger static powder blends. A comprehensive review of the scientific literature indicates that current sampling technology is plagued by a propensity for sampling bias. This limitation is particularly troublesome to the pharmaceutical industry which must then hold these samples to very high standards. In response to these concerns the PDA Solid Dosage Process Validation Committee has reviewed approaches to blend uniformity analysis. This technical report provides: a method to determine the appropriate sample size for each product, a holistic approach for establishing meaningful acceptance criteria, a discussion on the use of proper analytical techniques and recommendations for conducting investigations for out-of-specification results.

General method validation guidelines for pharmaceutical samples.

Method validation guidelines, which provide an organizational structure for the design and evaluation of a validation procedure, are presented for a wide range of pharmaceutical applications. The validation guidelines are based on the analyte concentration/sample matrix combination to which the method will be applied. These guidelines include the selection of appropriate validation parameters, design considerations for evaluation, and a discussion of acceptance guidelines for the determination of acceptable method performance. A set of tables is included which illustrates the selection and testing procedure and tailors the entire validation process to the specific characteristics of the determination to be made.