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Antimicrob Agents Chemother ; 56(6): 3417-9, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22391532

RESUMO

We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery. In the first episode of candidemia, an echinocandin-susceptible Candida glabrata strain was isolated, and the patient was treated with caspofungin. The isolates from the later episodes showed resistance to echinocandins. Analysis of the HS1 region of the FKS2 gene showed the amino acid substitution S663P. Microsatellite analysis demonstrated a strong genetic relationship between the isolates.


Assuntos
Antifúngicos/uso terapêutico , Candida glabrata/patogenicidade , Candidemia/microbiologia , Equinocandinas/uso terapêutico , Proteínas Fúngicas/genética , Idoso , Candida glabrata/genética , Candidemia/tratamento farmacológico , Caspofungina , Humanos , Lipopeptídeos , Masculino , Mutação
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