Linfoma no hodgkiniano primario de mama. Presentación inusual / Primary non-Hodgkin´s lymphoma of the breast. An unusual presentation

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Diagnóstico Doppler-color de Vasa Praevia / Diagnose Doppler-color of Vasa Praevia

La inserción velamentosa del cordón con vasos previos (vasa praevia o vasa previa) que cruzan por delante de la presentación, es una rara posibilidad diagnóstica que hay que tener en cuenta dado su potencial morbi-mortalidad fetal debido al sangrado procedente de estos vasos, de origen fetal, con posterior anemización y muerte en gran parte de los fetos si no se realiza un diagnostico con extracción fetal inmediata (AU)

[Hepatotoxicity induced by Droxicam: presentation of 4 cases]. / Hepatotoxicidad por Droxicam: presentación de 4 casos.

Hepatotoxicity has been reported with most of the nonsteroidal antiinflammatory drugs (NSAID). We describe four patients who presented hepatic injury after of treatment with Droxicam, a new NSAID prodrug of piroxicam. Hepatitis was attributed to Droxicam because of the absence of other etiological factors, temporal relation with drug administration, clinical, laboratory and histological picture and evolution favorable after the drug suppression. The hepatic injury was manifested as cholestasis and withdrawal of the drug was followed by biochemical and clinical improvement until the complete normalization in three of the four patients. Postmarketing surveillance is necessary in new drugs with unknown hepatotoxicity.

[Amyloidosis maculosa: diagnosis in primary care]. / Amiloidosis maculosa: diagnóstico en atención primaria.

Amyloidosis maculosa is a clinical entity with low incidence factor in our medium, which basically affects middle-aged women. The lesion is characterised by the presence of poorly defined, hyperpigmented, brownish or greyish maculae that converge and focus basically on the upper back and shoulders, usually accompanied by pruritus. Three patients were erroneously catalogued for years as having pityriasis versicolor. Two of these patients presented a typical clinical amyloidosis maculosa, and the third presented a less common manifestation of the disease: a single, well-defined lesion in the subscapular region. We believe that the approach to the diagnosis of pityriasis versicolor with hyperpigmented lesions that do not respond to specific treatment should be revised. Although amyloidosis maculosa has a low incidence in our medium, it is an entity which should not be discarded in these cases.

Colonic perforation by amyloidosis. Report of a case.

One patient with a colonic perforation associated with secondary amyloidosis and ankylosing rheumatoid spondylitis was treated successfully. To our knowledge, this is the first case described of colonic perforation in amyloidosis.

[Neuropathology of HIV infection]. / Neuropatología de la infección VIH.

Some references about the important neuropathologic lesions observed in patients with AIDS and about the variation on the relative incidence of the processes detected when analyzing clinic and neuropathologic tables, as well as a mention to the confusion created by terminological problems, clinicopathologic disagreement and wrong etiologic attributions, are used as an introduction to the exposition of HIV infection neuropathology. In a first section, Central Neuropathology is described, starting with the disorders considered as primarily caused by HIV. Then, infectious secondary Neuropathology, caused by different viruses, parasites, fungi or bacteria, and neoplastic secondary Neuropathology, mainly represented by localized lymphoma and by the uncommon Kaposi's disease, are analyzed. This section also includes references to cerebrovascular complications, Pediatric Neuropathology and ends with an analysis of cerebral biopsy indications. In the second part, Peripheral Neuropathology is described, splitting up peripheral nerve and muscle pathology.