[Expression of cluster of differentiation 74 in prostate cancer and its clinical significance].

OBJECTIVE: To study the expression of cluster of differentiation 74 (CD74) in PCa and its clinical significance. METHODS: Using immunohistochemical staining, we detected the expression of CD74 in 56 samples of PCa tissue and 55 samples of the adjacent BPH tissue. RESULTS: The rates of CD74 expression in the epithelial and stromal cells were 48.2% and 82.3% in the PCa tissue compared with 62.7% and 83.6% in the adjacent BPH tissue, with statistically significant difference between the two types of cells (P < 0.05 or P < 0.01), and those in the stromal cells of the PCa tissue with Gleason score ≤7 or >7 were 44.0% versus 80.8% (P < 0.05), while those in the epithelial cells of the PCa tissue with Gleason score ≤7 or >7 were 36.7% versus 61.5% (P > 0.01). CD74 was overexpressed in the poorly differentiated PCa cells and the surrounding stromal cells. CONCLUSIONS: CD74 may play an important role in the development and invasiveness of PCa, and is expected to be a prognostic indicator of the malignancy.

[Expressions of TFF1 and TFF3 in prostate cancer and prostatic intraepithelial neoplasia and their clinical significance].

OBJECTIVE: To explore the expressions of trefoil factor 1 (TFF1) and trefoil factor 3 (TFF3) in prostate cancer (PCa) and prostate intraepithelial neoplasia (PIN) and their clinical significance. METHODS: Using immunohistochemistry, we detected the expressions of TFF1 and TFF3 in the prostatic tissues of 89 cases of PCa, 50 cases of PIN, and 65 cases of benign prostate hyperplasia (BPH), and evaluated their clinical significance. RESULTS: The positive rates of TFF1 and TFF3 expressions were 77. 53% and 48. 31% in PCa and 66.00% and 30.00% in PIN, significantly higher than 49.23% and 13. 85% in BPH (P <0. 05). The expression of TFF1 was not correlated with Gleason score (P >0. 05), while that of TFF3 was significantly higher in the PCa cases with Gleason score ≤7 than in those with Gleason score > 7 (70. 00% vs 42. 03%, P <0. 05). No significant correlation was observed between TFF1 and TFF3 expressions in PCa (P >0. 05). CONCLUSION: The expressions of TFF1 and TFF3 may contribute to the occurrence and progression of PCa, and therefore could be used as laboratory indexes in the diagnosis, differential diagnosis, and prognosis of PCa.

[Expression of the epithelial cell adhesion molecule in prostate cancer and its clinical significance].

OBJECTIVE: To explore the expression of the epithelial cell adhesion molecule (EpCAM) in prostate cancer (PCa) and its clinical significance. METHODS: We collected tissue samples from 63 cases of PCa, 46 cases of prostatic intraepithelial neoplasia (PIN), and 58 cases of benign prostatic hyperplasia (BPH) adjacent to PCa and determined the expression of EpCAM in the epithelial and stromal cells by immunohistochemistry. RESULTS: The positive expression rates of EpCAM in the epithelial cells were significantly higher in PCa and PIN than in PCa-adjacent BPH (98. 4 and 97. 8 vs 51.7%, P <0. 01), and so was that in the stromal cells of PCa than in those of PCa-adjacent PIN (89.5 vs 50.0%, P <0.01). The expression of EpCAM.was remarkably higher in the stromal cells of bone metastasis than in those of non-bone metastasis tissue (100. 0 vs 40. 0%, P <0. 01) but showed no statistically significant differences between the highly and poorly differentiated PCa tissues (88.5 vs 91.9%, P >0.05). CONCLUSION: The expression level of EpCAM in the stromal cells of PCa is related to the occurrence, progression, and bone metastasis of the tumor, and therefore may be used as a marker in the early diagnosis of PCa as well as a predictor of bone metastasis of the tumor.