Effects of Yiqi Huoxue Tablet on Expression of Platelet Membrane Adhesion Molecules in Rats with Cerebral Infarction / 广州中医药大学学报

[Objective] To investigate the effects of Yiqi Huoxue Tablet (YHT, mainly composed of Radix Angelicae Sinensis, Herba Leonuri, Rhizoma Chuanxiong , Radix Astragali ) on expression of platelet membrane adhesion molecules (PMAM) in whole blood of rats with cerebral infarction. [Methods] Flow cytometry was used to detect the expression of PMAM (CD

Effects of Yiqi Huoxue Tablet on Nerve Cell Apoptosis and Expression of Related Gene in Rats with Cerebral Ischemia / 广州中医药大学学报

[Objective] To observe the apoptosis of cortical cells and expression of related gene bcl-2 in hippocampal gyrus and frontal lobe of rats with incomplete cerebral ischemia (ICI) and to investigate the effects of Yiqi Huoxue Tablet (YHT, mainly composed of Radix Astragali , Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Leonuri, Rhizoma Acori Tatarinowii, Scorpio, etc) . [ Methods ] Rats were randomized into six groups: model group, mimic operation group, nimodipine group and low-dose, moderate-dose and high-dose YHT groups. Flow cytometry was used to detect the apoptotic rate and bcl-2 protein content in cortical cells. Histological changes were also observed under light microscope. [Results] Early apoptotic changes were found in the model group and the apoptotic rate and bcl-2 protein content were higher than those in the mimic operation group; after treatment of YHT, the apoptotic rate in frontal lobe was decreased as compared with that in the model group and that in hippocampal gyrus remained higher than that in the mimic operation group and bcl-2 protein content was reduced to the level of the mimic operation group. [ Conclusion ] ICI is related to the apoptosis of nerve cells and YHT has been proved an effectual drug for the apoptosis.

Regulatory Effects of Toutong Xin No. 1 on Nitric Oxide and Nitric Oxide Synthetase Levels in the Plasma and Platelet of Migraineurs / 广州中医药大学学报

[Objective] To investigate effects Toutong Xin No.l (TX1) on nitric oxide (NO) and nitric oxide synthetase (NOS) levels in platelet and plasma of migraineurs during episode and remission and to explore its mechanism. [Methods] NO and NOS levels in platelet and plasma of migraineurs during episode and remission were measured and were compared with those of healthy volunteers (Group A). [Results] NO and NOS levels in the plasma of migraineurs during episode (Group B) were higher than those during remission (Group C) and Group A (P

Clinical Observation on 46 Cases of Alzheimer's Disease Treated with Yishen Bunao Tablet / 中医杂志

Objective:To investigate the effect of Yishen Bunao Tablet on Alzheimer's Disease(AD).Methods:91 cases of AD were randomly divided into a treatment group(n=46)treated with Yishen Bunao Tablet and a control group(n=45)treated with huperzine A. Their clinical therapeutic effects,changes of superoxide dismutase(SOD)activity,malondialdehyde(MDA)and nitric oxide(NO) contents before and after treatment were determined.Results:There was no significant difference between the two groups in the total therapeutic effect;After treatment,the scores for language comprehend and order obey in the treatment group increased significantly(P0.05).SOD activity increased significantly,and contents of MDA and NO decreased significantly in the control group(P