Primary meningeal central nervous system lymphoma: A case report and literature review.

RATIONALE: Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma, and isolated meningeal PCNSL, without evidence of parenchymal involvement, is even less common, occurring in only 10% to 15% of cases. PATIENT CONCERNS: A 65-years-old female presented to our hospital with progressive lower extremity motor dysfunction and blurred vision. The initial neurological examination revealed decreased muscle strength in both lower extremities and sensory dysfunction of lower extremities, saddle area, and buttocks. Brain magnetic resonance imaging showed no abnormalities. Lumbar enhanced magnetic resonance imaging showed T11 to L3 horizontal meningeal enhancement. Cerebrospinal fluid (CSF) cytology revealed lymphoma cells. Immunohistochemistry and flow cytometry of the CSF were performed as auxiliary methods to establish the diagnosis of lymphoma. DIAGNOSES: The patient was diagnosed primary meningeal central nervous system lymphoma. INTERVENTIONS: During hospitalization, the patient was treated with 2 courses of high-dose intrathecal methotrexate and rituximab combined with intrathecal chemotherapy and supportive treatment. OUTCOMES: After 2 years of follow-up, the patient was able to walk and take care of herself. LESSONS: Cases of PCNSL involving only the meninges are rare. Multimodal analysis of the CSF comprises an important component of the diagnostic work-up for patients with primary meningeal central nervous system lymphoma.

The Influence of Negative Life Events on Suicidal Ideation in College Students: The Role of Rumination.

This study aimed to investigate the influence of negative life events on suicidal ideation in college students and the role of rumination. Using a cluster sampling method, 894 college students were asked to fill out the adolescent life event scale, ruminative response scale, and suicidal ideation scale. The study revealed the following: (1) negative life events, rumination, and suicidal ideation were significantly positively correlated with each other; (2) rumination played a full mediating role in the influence of negative life events on suicidal ideation; and (3) rumination also played a moderating role in the influence of negative life events on suicidal ideation. Under a high level of rumination, negative life events had a significant positive effect on suicidal ideation in college students; however, under a low level of rumination, negative life events did not have a significant effect on suicidal ideation. Rumination played mediating and moderating roles in the relationship between negative life events and suicidal ideation among college students.