Vitamin B levels in blood serum and brain MRI changes in patients with H-type hypertension / 中华神经医学杂志

Objective To investigate the levels of plasma homocysteine (Hcy),serum folic acid and serum vitamin B12 in patients with H-type hypertension to provide some reference for intervening the white matter lesions. Methods One hundred and ten patients with hypertension (78 with H-type hypertension and 32 with hypertension),admitted to our hospital from April 2010 to March 2011,and other 50 healthy controls were chosen in our study; plasma Hcy level and serum folic acid and vitamin B12 levels were measured by using radioimmunoassay among control group,hypertension group and H-type hypertension group.White matter lesion changes of all patients were evaluated by MRI. Results The plasma Hcy level and serum folic acid and vitamin B12 levels in H-type hypertension group were significantly higher than those in control group and hypertension group (P＜0.05); the degree of white matter lesions was significantly different between each 2 groups (P＜0.05): the patients of H-type hypertension group had the most obvious white matter lesions, following by hypertension group and control group. Conclusion The patients with H-type hypertension have decreased folic acid and vitamin B12 levels and severe white matter lesion changes, which might be correlated with hyperhomocysteinemia.

Sequence analysis of norovirus CHN02/LZ35666 from Lanzhou city of China based on RdRp and VP1 genes / 病毒学报

Sequence analysis of a new norovirus (NV) isolated from Lanzou city of China was performed based on partial sequence of RNA dependent RNA polymerase (RdRp) and complete capsid protein (VP1) gene. The isolated strain CHN02/LZ35666 shared high sequence homology with GII-4 NVs. Nucleotide homologies of RdRp region and encoded capsid protein region were 90.4% -- 98.6% and 89.8% -- 95.7% , respectively, while amino acid homology of capsid protein region was 94.4% -- 97.4%. The analysis of GDD motif in RdRp region indicated this GDD motif of Lanzhou strain differed from those of the GII-4 predominant epidemic strains. Lanzhou strain formed an independent branch in GII-4 cluster in the phylogenetic tree based on nucleotide sequence of RdRp region and amino acid sequence of capsid protein. Sequence alignment revealed a mutation at the fourth key site of the receptor-binding interface in the strains isolated after 2002 compared with those of previous strains suggesting a possible change of binding pattern to HBGAs receptors.