1.
Biologicals
; 37(6): 416; discussion 421-3, 2009 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19758822
RESUMO
Application of the principles outlined in the WHO Guideline on Stability Evaluation of Vaccines is complicated by the nature of combination vaccines. Differences in degradation rates among the immunogens impose the restriction that shelf life is based on the most labile component. There is also a testing challenge with numerous components held at different stages of production.