RESUMO
Two cases of subacute sensory neuronopathy (SSN) associated with small cell lung cancer are reported. In both cases motor disability, attributed to motor neuropathy and neuronopathy, respectively, accompanied SSN. Immunohistochemical studies performed provide further data suggesting the involvement of humoral antibodies and the participation of protease inhibitors in the pathogenesis of SSN.
Assuntos
Encéfalo/patologia , Carcinoma de Células Pequenas/patologia , Neoplasias Pulmonares/patologia , Doenças Neuromusculares/patologia , Síndromes Paraneoplásicas/patologia , Transtornos de Sensação/patologia , Medula Espinal/patologia , Autoanticorpos/análise , Encéfalo/imunologia , Carcinoma de Células Pequenas/imunologia , Complemento C3/análise , Ferritinas/análise , Gânglios Espinais/imunologia , Gânglios Espinais/patologia , Proteína Glial Fibrilar Ácida/análise , Humanos , Doenças do Complexo Imune/imunologia , Doenças do Complexo Imune/patologia , Técnicas Imunoenzimáticas , Imunoglobulina G/análise , Imunoglobulina M/análise , Neoplasias Pulmonares/imunologia , Masculino , Pessoa de Meia-Idade , Degeneração Neural/fisiologia , Doenças Neuromusculares/imunologia , Síndromes Paraneoplásicas/imunologia , Transtornos de Sensação/imunologia , Medula Espinal/imunologia , alfa 1-Antiquimotripsina/análiseRESUMO
The clinical findings, EEG and CT examinations of the brain were compared at three time intervals in patients with ischaemic stroke. No evident correlation was found between the intensity of clinical signs, the intensity of EEG changes and the size of the ischaemic focus in the CT. It was observed that with increasing time interval after the onset of the disease the clinical state and EEG changes improved while the CT image was not changed or even became worse. In the observations a greater tendency clinical for improvement was found in the group of cases of lesions in the left parietal lobe than in those with lesions in the right parietal lobe. Another observation was that patients with ischaemic focus developing in brain with evidence of atrophy in CT had a much lower tendency for clinical improvement than those without brain atrophy.