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1.
Artif Cells Nanomed Biotechnol ; 41(6): 359-62, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23368749

RESUMO

In the area of water purification, nanotechnology provides efficient removal of pollutants and germs. Electrospun nanofibers membrane has a potential for water purification due to its high large surface area, and good mechanical strength. In the present study, PAMAM dendrimers composite nylon-6 nanofibers membrane was prepared by crosslinking method using glutaraldehyde. Modified membrane has drastically improved water purification efficiency. Further, the efficacy of the modified membrane can be renewed by mere exposure of the saturated membrane with the solution having acidic pH. The modified membrane can be used as an effective tool for water purification.


Assuntos
Membranas Artificiais , Nanofibras/química , Purificação da Água/métodos , Caprolactama/análogos & derivados , Caprolactama/química , Dendrímeros/química , Concentração de Íons de Hidrogênio , Lítio/química , Lítio/isolamento & purificação , Polímeros/química , Microbiologia da Água
2.
Artigo em Inglês | MEDLINE | ID: mdl-20553201

RESUMO

The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits.


Assuntos
Alginatos/química , Alginatos/farmacologia , Descoberta de Drogas/métodos , Metronidazol/química , Microesferas , Peptídeo Hidrolases/metabolismo , Cicatrização/efeitos dos fármacos , Alginatos/metabolismo , Animais , Cloreto de Cálcio/química , Química Farmacêutica , Colágeno/metabolismo , Emulsões , Ácido Glucurônico/química , Ácido Glucurônico/metabolismo , Ácido Glucurônico/farmacologia , Ácidos Hexurônicos/química , Ácidos Hexurônicos/metabolismo , Ácidos Hexurônicos/farmacologia , Masculino , Tamanho do Órgão/efeitos dos fármacos , Tamanho da Partícula , Coelhos , Pele/efeitos dos fármacos , Pele/metabolismo , Pele/patologia
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