Influence of the Duty Cycle of Pulse Electrodeposition-Coated Ni-Al2O3 Nanocomposites on Surface Roughness Properties.

In this study, the viability of duty cycle variation was explored as a potential method to improve the mechanical and surface roughness properties of Ni-Al2O3 nanocoatings through pulse electrodeposition. The areal and surface roughness properties of nanocomposite pulse electrodeposition-coated materials with varying duty cycles from 20% to 100% was studied with the analysis of bearing area curves and power spectral densities. Results demonstrate that with decrease in duty cycle, there was an enhancement in aerial roughness properties from 0.348 to 0.195 µm and surface roughness properties from 0.779 to 0.245 µm. The change in surface roughness was due to grain size variation, resulting from the varying time intervals during pulse coatings. This increase in grain size with the change in duty cycle was confirmed with the scanning electron microscope. In addition, an increase in grain size from 0.32 to 0.92 µm with an increase in duty cycle resulted in a decrease in nanohardness from 4.21 to 3.07 GPa. This work will provide a novel method for obtaining Ni-Al2O3 nanocomposite coatings with improved surface roughness and hardness properties for wider industrial applications.

Neuromodulation as a new avenue for resuscitation in hemorrhagic shock.

Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33-56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.