Associations between occupational therapy students' academic performance and their study approaches and perceptions of the learning environment.

BACKGROUND: Relationships between students' academic performance and their employed study approaches have been studied extensively. However, research using study approaches and learning environment factors as concurrent predictors of academic performance is sparse. There is a need to disentangle the potentially interrelated influences of individual and contextual factors on students' academic performance. OBJECTIVE: This study aimed to increase the understanding of the associations between occupational therapy students' academic performance, and their approaches to studying, perceptions of the learning environment, and sociodemographic characteristics. METHOD: A cross-sectional study was designed, and 174 first-year students completed the Approaches and Study Skills Inventory for Students and the Course Experience Questionnaire, in addition to background information. Data on grades were collected from the data registries of each education institution, and associations were analyzed by multiple linear regression. RESULTS: None of the learning environment scales were associated with grades. Adjusting for all variables, better exam results were associated with being female (ß = 0.22, p < 0.01) and having higher scores on strategic approach (ß = 0.31, p < 0.001) and lower scores on surface approach (ß = -0.20, p < 0.01). CONCLUSION: The study suggests that students with a desire for obtaining good grades ought to use strategic study behaviors and avoid using surface approach behaviors. While it is important to ensure good quality of the learning environment for a variety of reasons, the learning environment did not contribute significantly to explain the students' academic performance.

Efficient, designable, and broad-bandwidth optical extinction via aspect-ratio-tailored silver nanodisks.

Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are 2-10x more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies.

Design of diamond microcavities for single photon frequency down-conversion.

We propose monolithic diamond cavities that can be used to convert color-center Fock-state single photons from emission wavelengths to telecommunication bands. We present a detailed theoretical description of the conversion process, analyzing important practical concerns such as nonlinear phase shifts and frequency mismatch. Our analysis predicts sustainable power requirements (≲ 1 W) for a chipscale nonlinear device with high conversion efficiencies.

Robust topology optimization of three-dimensional photonic-crystal band-gap structures.

We perform full 3D topology optimization (in which "every voxel" of the unit cell is a degree of freedom) of photonic-crystal structures in order to find optimal omnidirectional band gaps for various symmetry groups, including fcc (including diamond), bcc, and simple-cubic lattices. Even without imposing the constraints of any fabrication process, the resulting optimal gaps are only slightly larger than previous hand designs, suggesting that current photonic crystals are nearly optimal in this respect. However, optimization can discover new structures, e.g. a new fcc structure with the same symmetry but slightly larger gap than the well known inverse opal, which may offer new degrees of freedom to future fabrication technologies. Furthermore, our band-gap optimization is an illustration of a computational approach to 3D dispersion engineering which is applicable to many other problems in optics, based on a novel semidefinite-program formulation for nonconvex eigenvalue optimization combined with other techniques such as a simple approach to impose symmetry constraints. We also demonstrate a technique for robust topology optimization, in which some uncertainty is included in each voxel and we optimize the worst-case gap, and we show that the resulting band gaps have increased robustness to systematic fabrication errors.

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.

Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin-induced myopathy.

Fundamental limits to extinction by metallic nanoparticles.

We show that there are shape-independent upper bounds to the extinction cross section per unit volume of dilute, randomly arranged nanoparticles, given only material permittivity. Underlying the limits are restrictive sum rules that constrain the distribution of quasistatic eigenvalues. Surprisingly, optimally designed spheroids, with only a single quasistatic degree of freedom, reach the upper bounds for four permittivity values. Away from these permittivities, we demonstrate computationally optimized structures that surpass spheroids and approach the fundamental limits.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.

Cystic fibrosis (CF) is a life-shortening disease arising as a consequence of mutations within the CFTR gene. Novel therapeutics for CF are emerging that target CF transmembrane conductance regulator protein (CFTR) defects resulting from specific CFTR variants. Ivacaftor is a drug that potentiates CFTR gating function and is specifically indicated for CF patients with a particular CFTR variant, G551D-CFTR (rs75527207). Here, we provide therapeutic recommendations for ivacaftor based on preemptive CFTR genotype results.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens.

Pegylated interferon-α (PEG-IFN-α or PEG-IFN 2a and 2b)- and ribavirin (RBV)-based regimens are the mainstay for treatment of hepatitis C virus (HCV) genotype 1. IFNL3 (IL28B) genotype is the strongest baseline predictor of response to PEG-IFN-α and RBV therapy in previously untreated patients and can be used by patients and clinicians as part of the shared decision-making process for initiating treatment for HCV infection. We provide information regarding the clinical use of PEG-IFN-α- and RBV-containing regimens based on IFNL3 genotype.

Casimir forces on a silicon micromechanical chip.

Quantum fluctuations give rise to van der Waals and Casimir forces that dominate the interaction between electrically neutral objects at sub-micron separations. Under the trend of miniaturization, such quantum electrodynamical effects are expected to play an important role in micro- and nano-mechanical devices. Nevertheless, utilization of Casimir forces on the chip level remains a major challenge because all experiments so far require an external object to be manually positioned close to the mechanical element. Here by integrating a force-sensing micromechanical beam and an electrostatic actuator on a single chip, we demonstrate the Casimir effect between two micromachined silicon components on the same substrate. A high degree of parallelism between the two near-planar interacting surfaces can be achieved because they are defined in a single lithographic step. Apart from providing a compact platform for Casimir force measurements, this scheme also opens the possibility of tailoring the Casimir force using lithographically defined components of non-conventional shapes.

The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.

Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly.

Exploration of in-fiber nanostructures from capillary instability.

A new class of multi-material fiber that incorporates micrometer-thickness concentric-cylindrical sheets of glass into polymer matrix has emerged. The ultimate lower limit of feature size and recent observation of interesting instability phenomenon in fiber system motivate us to examine fluid instabilities during the complicated thermal drawing fabrication processing. In this paper, from the perspective of a single instability mechanism, classical Plateau-Rayleigh instabilities in the form of radial fluctuation, we explore the stability of various microstructures (such as shells and filaments) in our composite fibers. The attained uniform structures are consistent with theoretical analysis. Furthermore, a viscous materials map is established from calculations and agrees well with various identified materials. These results not only shed insights into other forms of fluid instabilities, but also provide guidance to achieve more diverse nanostructures (such as filaments, wires, and particles) in the microstructured fibers.

Anomalous dispersion relations by symmetry breaking in axially uniform waveguides.

We show that modes of axially uniform waveguides of arbitrary cross section can be made to have anomalous dispersion relations resulting from strong repulsion between two modes. When the axial wave vector k is 0, the two modes have different TE/TM symmetry and thus can be brought arbitrarily close to an accidental frequency degeneracy. For nonzero k, the symmetry is broken causing the modes to repel. When the modes are sufficiently close together this repulsion leads to unusual features such as extremely flattened dispersion relations, backward waves, zero group velocity for nonzero k, atypical divergence of the density of states, and nonzero group velocity at k=0.

Polarization-independent linear waveguides in 3D photonic crystals.

Using a symmetry-based approach, we have designed polarization-independent waveguides in a 3D photonic crystal. A comprehensive series of numerical experiments, involving the propagation of pulsed signals through long straight waveguide sections and sharp bends, quantitatively evaluates the bend-transmission coefficient over the entire bandwidth of the corresponding guided modes. High (approximately 95%) polarization-independent bend transmission is achieved within a certain frequency range.

Low-loss, wide-angle Y splitter at approximately ~1.6- mum wavelengths built with a two-dimensional photonic crystal.

We report a successful experimental realization of a photonic-crystal Y splitter operating at lambda~1.6 mum . Our device has a large splitting angle of 120 degrees and a miniature size of ~3 mumx3 mum . Furthermore, the Y-splitter loss is measured to be 0.5-1 dB at lambda=1640-1680 nm, making the Y splitter promising for integrated photonic-circuit applications. These unique properties are attributed to the new guiding principle made possible by the photonic bandgap.

Electromagnetic cavity with arbitrary Q and small modal volume without a complete photonic bandgap.

We show how an electromagnetic cavity with arbitrarily high Q and small (bounded) modal volume can be formed in two or three dimensions with a proper choice of dielectric constants. Unlike in previous work, neither a complete photonic bandgap nor a trade-off in mode localization for Q is required. Rather, scattering and radiation are prohibited by a perfect mode match of the TE-polarized modes in each subsection of a Bragg resonator. Q values in excess of 10(5) are demonstrated through finite-difference time-domain simulations of two- and three-dimensional structures with modal areas or volumes of the order of the wavelength squared or cubed.

Quantitative analysis of bending efficiency in photonic-crystal waveguide bends at lambda = 1.55 mum wavelengths.

Based on a photonic-crystal slab structure, a 60 degrees photonic-crystal waveguide bend is successfully fabricated. Its bending efficiency within the photonic bandgap is measured, and near 100% efficiency is observed at certain frequencies near the valence band edge. The bending radius is ~1mum at a wavelength of lambda~1.55mum . The measured eta spectrum also agrees well with a finite-difference time-domain simulation.

Direct measurement of the quality factor in a two-dimensional photonic-crystal microcavity.

A new microcavity design is proposed and structures are realized with a two-dimensional photonic-crystal slab. The cavity consists of seven defect holes that encompass a hexagon and is designed to reduce vertical light leakage. From a direct transmission measurement, a Q value of 816+/-30 is achieved at lambda =1.55 mum . This high- Q cavity will permit the realistic realization of spontaneous-emission modification and on-off optical switches.

Three-dimensional control of light in a two-dimensional photonic crystal slab.

Optoelectronic devices are increasingly important in communication and information technology. To achieve the necessary manipulation of light (which carries information in optoelectronic devices), considerable efforts are directed at the development of photonic crystals--periodic dielectric materials that have so-called photonic bandgaps, which prohibit the propagation of photons having energies within the bandgap region. Straightforward application of the bandgap concept is generally thought to require three-dimensional (3D) photonic crystals; their two-dimensional (2D) counterparts confine light in the crystal plane, but not in the perpendicular z direction, which inevitably leads to diffraction losses. Nonetheless, 2D photonic crystals still attract interest because they are potentially more amenable to fabrication by existing techniques and diffraction losses need not seriously impair utility. Here we report the fabrication of a waveguide-coupled photonic crystal slab (essentially a free-standing 2D photonic crystal) with a strong 2D bandgap at wavelengths of about 1.5 microm, yet which is capable of fully controlling light in all three dimensions. These features confirm theoretical calculations on the possibility of achieving 3D light control using 2D bandgaps, with index guiding providing control in the third dimension, and raise the prospect of being able to realize unusual photonic-crystal devices, such as thresholdless lasers.

Population structure, parasitism, and survivorship of sexual and autodiploid parthenogenetic Campeloma limum.

Two theories for the maintenance of sexual reproduction, the Red Queen hypothesis and mutation accumulation, suggest that the dispersal rates of sexuals and asexuals may determine the elimination or persistence of asexuals. Under higher dispersal rates of asexuals, asexuals may temporarily escape virulent parasites and reduce the effects of deleterious mutations. In the present study, I examine the population structure, parasite loads, and juvenile survivorship of Campeloma limum sexuals and autodiploid parthenogens from the southeastern U.S. Atlantic coastal plain. Using mtDNA sequence variation, it is shown that parthenogenetic haplotypes with limited sequence divergence are geographically widespread throughout this region and there is no significant population differentiation over a broad geographical scale. Sexual C. limum populations show significant mtDNA differentiation among and within river drainages and there is significant isolation by distance. These patterns are consistent with a recent origin and range expansion of parthenogens. Prevalence of infection by digenetic trematodes is significantly higher in autodiploid parthenogens, and the variance of prevalence is also higher in autodiploid parthenogens. I argue that the latter pattern indicates that unparasitized parthenogens have temporarily escaped these virulent parasites, but recolonization of these populations by trematodes results in high infection levels (> 40%), possibly due to reduced variation in resistance genes. I also examined whether the survivorship of juvenile sexuals and parthenogens varied under different stress levels. Sexual juveniles had twofold higher survivorship in all environments. Compared to polyploid parthenogens, autodiploid parthenogens may be less buffered against the effects of deleterious recessive alleles. I propose that the combined effects of higher parasitism and reduced juvenile survivorship of these autodiploid parthenogens accounts for the spatial distribution of sexual and parthenogenetic C. limum in the Atlantic coastal plain. Parthenogens may persist by higher dispersal rates into marginal habitats where there is a temporary escape from digenetic trematodes and competition with sexuals.