Toxicity of monomers HEMA, DEGMA and AEMA, used in synthesis of hydrogels for medical applications.

Acute toxicity parameters (lethal doses) were evaluated and calculated after i.m. and i.p. administration of 2-hydroxyethyl methacrylate (HEMA), 2-(hydroxyethoxy)ethyl methacrylate (DEGMA) and 2-(acetoxy)ethyl methacrylate (AEMA) to rats. Our previous findings were revisited and corrected. Based on preceding standardization and physiological values study, some clinical chemical and hematological markers of in vivo subacute i.m. toxicity were followed. Hematological parameters revealed to be of low sensitivity to the toxic influence. Clinical chemical tests suggest the prevalent muscle cell injury.

Hormesis in effect of low uranium doses on organisms.

Uranium nitrate applied daily in small amounts per os (0.5-17 mg/l in drinking water) or per cuttim (0.2-0.8 g/kg) exerts positive effect on metabolism of phosphate ions by red blood cells in vitro. This positive effect changes to the negative one with increasing dose or exposure time. It may be assumed that most other cells in the organism are affected in the same way as erythrocytes and that similar effect might be observed with other harmful agents or substances.