[Zollinger-Ellison syndrome in children caused by hyperplasia of antral gastrin cells]. / Syndrome de Zollinger-Ellison chez l'enfant par hyperplasie des cellules à gastrine antrales.

A case of Zollinger-Ellison due to hyperplasia of antral gastrin cells in a 11 year-old child is reported. Only 49 cases of this syndrome in children have been published. The diagnosis (gastrin stimulation test, immunohistochemical detection of endocrine cells and therapeutic strategy are outlined).

[Study of the effectiveness of tiapride on psychic disorders in alcoholics]. / Etude de l'effeicacité du tiapride sur les troubles psychiques de l'alcoolique.

The effectiveness of tiapride on psychic disorders was studied in 30 chronic alcoholics by assessing four parameters: sleep disturbances, mood disorders, conduct disturbances, and tremor. In a daily dosage of 600 to 900 mg tiapride proved particularly effective on insomnia, anxiety, passivity and tremor, without adverse side-effects. This drug seems useful for controlling psychic disorders in alcoholics and for motivating acceptance of a detoxification program.

[Genetic deficiency of thyroxin-binding protein in 4 members of a family (author's transl)]. / Déficit génétique en globuline fixant la thyroxine chez quatre membres d'une famille.

Four members of the same family (2 male and 2 female) with normal thyroid function were found to have decreased total T3 and total T4, elevated response to the T3 test and low free thyroxin index. Such biological changes result from a deficiency in carrier protein and should be distinguished from nearly similar abnormalities observed in low T3 syndrome and hypothyroidism. Whilst gonosomal transmission through the X chromosome of thyroxin-binding protein deficiency seems well established, our findings show that another mechanism, i.e. dominant autosomal heredity, is practically certain.

[Chronic hepatitis in sex linked agammaglobulinemia. One case (author's transl)]. / Hépatite chronique au cours d'une agammaglobulinémie liée au sexe. Une observation.

The authors report the case of a 21 years old man, with sex-linked agammaglobulinemia, who presents a presumed viral hepatitis, followed two years. The evolution, does yet fear a progressive cirrhosis. About this report and analysis of literature, frequency, evolution and pathophysiologic hypothesis, particularly the lymphocyte T role, are also discussed as the problem of hepatitis prevention of these subjects, who receive gammaglobulin injections.

[Nontuberculous infectious osteoarthritis in adults (excluding spondylodiscitis) in rheumatology]. / Ostéo-arthrites infectieuses non tuberculeuses de l'adulte (spondylodiscites exceptées) en milieu rhumatologique

Analysis of twenty five personal observations of septic osteoarthritis compared with information from the literature led the authors to the following conclusions: 1) Diagnosis of septic osteo-arthritis must be considered when confronted with a picture of acute or subacute arthritis generally inflamed with variable fever, raised sedimentation rates and frequently polymorph neutrophilia, above all especially if there are particular antecedents (local trauma or intra-articular injection, conditions which favor infections: diabetes, alcoholism, impaired immunity, corticosteroid therapy or various therapeutic immuno-suppresives). 2) It may be established on absolute criteria (isolation of the organism at the site of the lesions) or, in the absence of direct bacteriological evidence, by a body of evidence amongst which 4 arguments are of particular value: identification of a pathogenic organism in one or more blood cultures and/or at the site of a closed infection, postive serology and particularly elevation of the antistaphylolysine titres, rapid-onset radiological changes of destruction and/or reconstruction. plus hypercellularity of the fluid greater than 100,000 cells/mm3. 3) Medical treatment sometimes includes local treatment (joint aspiration, local injection of antibiotics) and in all cases immobilisation during the acute phase and systemic antibiotics. The latter will vary according to the organism responsible and its sensitivity. It seems useful to continue this for twelve weeks at the minimum in the normal form, initially making use of the combination of 2 antibiotics and preferably using continuous perfusion and/or intramuscular routes during the first half of treatment. 4) The consistently good results of such medical treatment seem to limit considerably the place of surgery for which the indications have become rare during the acute phase and even more so at later stages.