The effect of single- or multiple-layered garments on interface pressure measured at the backpack-shoulder interface.

Experiments were aimed at determining whether interface pressure measurements are a true reflection of skin contact pressure when made over different layers of clothing. Interface pressures were recorded at the skin interface and above clothing layers, with 11 participants wearing 10 different clothing combinations. The clothing used was standard issue British military clothing, including body armour (without ballistic plate). Participants wore both single and multiple clothing layers whilst walking on a treadmill carrying a loaded backpack (23.5 kg, British military issue). Results showed no significant differences (p=>0.05) in pressure between different clothing layers either singly, or worn in multiple. In conclusion, the soldier (or leisure user) will gain no or very little relief from applied pressure by wearing garments, even in layers, when carrying a backpack. Also, the findings suggest that interface pressure may adequately be assessed using a sensor placed above the clothing layer(s) rather than at skin surface.

Prophylactic urokinase in the management of long-term venous access devices in children: a Children's Oncology Group study.

PURPOSE: Infection and thrombosis are serious complications of long-term vascular access devices in children undergoing chemotherapy. Since routine fibrinolytic therapy may decrease these complications, the purpose of this study was to compare the efficacy of an every-2-week administration of urokinase with standard heparin flushes in reducing the incidence of device-related infections and occlusions. MATERIALS AND METHODS: This study was a prospective, randomized phase III multicenter trial conducted by the Children's Cancer Group, in which patients with implantable ports or tunneled catheters received either urokinase or heparin every 2 weeks for 12 months. Study end points were time to first occlusion or time to first device-related infection. RESULTS: Five hundred seventy-seven patients from 29 institutions were enrolled, of whom 51% had external catheters and 49% had ports. Urokinase administration resulted in fewer occlusive events than heparin (23% v 31%; P =.02), a longer time to first occlusive event (log-rank analysis, P =.006), and a 1.6-fold difference in the rate of occlusive events (Poisson regression, P =.003). Similar results were noted when comparing ports and tunneled catheters. The urokinase group also had a 1.4-fold difference in the rate of infection (Poisson regression, P =.05) and longer time to first infection (log-rank, P =.07), but the difference was significant only in tunneled catheters. CONCLUSION: Urokinase administration every 2 weeks significantly affects the rate of occlusive events in ports and tunneled catheters and of infectious events in external catheters compared with heparin administration.