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Bioorg Med Chem
; 13(12): 3899-909, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15911306
RESUMO
A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with K(i) values ranging from 430 to 580 nM.