RESUMO
The biological activities of vitamin E are related to the cellular functions and presence of sufficient tissue concentrations of this micronutrient. Most of the stored vitamin E is in the adipose tissue where it appears to be distributed equally. The breast adipose tissue has similar vitamin E concentrations as other parts of the body. The ductal systems also store vitamin E in sufficient concentrations to maintain cellular functions. The milk secreted from the ducts of the breast contains a high concentration of tocopherol. Whereas the normal breast tissue presumably utilizes vitamin E as an antioxidant, tumor tissue appears to handle vitamin E differently. Breast tumors possessing estrogen negative receptors and having poor histological differentiation have lower concentrations of vitamin E than tumors with positive estrogen receptors and well differentiated histology. Since vitamin E is considered the principal, if not sole, chain-breaking lipophilic antioxidant in plasma and tissue, its role as a potential chemopreventive agent in breast cancer should be further investigated. The combination of vitamin E with other cancer chemopreventive agents appears to be a reasonable procedure.
Assuntos
Neoplasias da Mama/prevenção & controle , Vitamina E/farmacocinética , Tecido Adiposo/química , Tecido Adiposo/metabolismo , Tecido Adiposo/patologia , Administração Oral , Adulto , Idoso , Mama/química , Mama/metabolismo , Mama/patologia , Neoplasias da Mama/química , Neoplasias da Mama/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Leite Humano/química , Projetos Piloto , Distribuição Tecidual , Vitamina E/análise , Vitamina E/farmacologiaRESUMO
A different approach to the management of inguinal hernia was studied in relation to pertinent anatomy, classification of hernia type, operative technique, early ambulation length of disability and hospitalization and follow-up. Hospitalization and disability were reduced by 50 per cent at the same time that the recurrence rate was reduced.