RESUMO
Technical details of an improved method for measuring tensile behaviour of normal and treated rat skin are described. The apparatus has been developed specifically for skin specimens so that the extending force and the adequate strain rate until rupture are designed especially for this purpose. Skin is to be mounted in the jaws of the instrument in horizontal position. Preliminary biological data have been worked out.
Assuntos
Anti-Inflamatórios/farmacologia , Fluocortolona/farmacologia , Pregnadienodiois/farmacologia , Fenômenos Fisiológicos da Pele , Administração Tópica , Animais , Fluocortolona/análogos & derivados , Hidrocortisona , Masculino , Fisiologia/instrumentação , Ratos , Pele/efeitos dos fármacos , Resistência à Tração/efeitos dos fármacosRESUMO
Different concentrations of butyl 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester FCB, Vaspit) and of clobetasone-17-butyrate, clobetasole-17-propionate and hydrocortisone-17-butyrate have been administered topically in order to investigate dermal and systemic side effects. It could be shown that FCB exhibits by far the least side effects. A specially devised apparatus covering the site of substance application, guaranteed an exclusive dermal absorption. Side effects, therefore, cannot be ascribed to oral ingestion of the drugs.