Treatment outcomes and associated factors among patients with drug-sensitive tuberculosis on daily fixed-dose combination drugs: A cohort study from Ahmedabad, India.

Background and Aim: The National Tuberculosis Elimination Program (NTEP) has been progressive in addressing the issues related to tuberculosis (TB) control in the country, with constant programmatic changes based on evidence available from operational research. Our objectives were 1. to assess the sociodemographic and clinical characteristics, and the treatment outcomes of patients on fixed-dose combination (FDC) daily regimen and 2. to assess the factors associated with unsuccessful treatment outcomes among patients with DS-TB. Materials and Methods: A retrospective cohort study was conducted based on record review. The study population included all patients with drug-sensitive TB, registered and initiated on treatment under NTEP "new category" from January to June 2018 and under "previously treated category" from January to March 2018. Quantitative data downloaded from Nikshay in Excel format was imported. Results: A total of 8301 patients with DS-TB registered under NTEP. Mean (standard deviation [SD]) age of DS-TB patients was 35.3 + 16.9 years, and 63.2% were in the age group of 15-44 years. Also, 60.1% were male, 2.5% were human immunodeficiency virus (HIV) positive, 65.3% were pulmonary TB cases, and 70.4% obtained treatment from public providers. Proportion of "successful" and "unsuccessful" outcomes was 87.9% and 12.1%, respectively, in the new treatment category and 78.3% and 21.7%, respectively, in the previously treated category. Among the patients classified under new category, the unsuccessful treatment outcome remained significantly high after adjustments with known confounders among patients aged 45-54 years (adjusted relative risks [aRR] 1.59, 95% confidence interval [CI] 1.31-1.93) and 55-64 years (aRR 1.67, 95% CI 1.36-2.05) compared to patients aged <15 years. Conclusion: Unsuccessful treatment outcome was significantly high among patients aged 45-54 years. Various adherence mechanisms implemented can be evaluated for further upscaling and improving the program effectiveness.

Assessing seropositivity for IgG antibodies against SARS-CoV-2 in Ahmedabad city of India: a cross-sectional study.

OBJECTIVES: To study the percentage seropositivity for SARS-CoV-2 to understand the pandemic status and predict the future situations in Ahmedabad. STUDY DESIGN: Cross-sectional study. SETTINGS: Field area of Ahmedabad Municipal Corporation. PARTICIPANTS: More than 30 000 individuals irrespective of their age, sex, acute/past COVID-19 infection participated in the serosurvey which covered all the 75 Urban Primary Health Centres (UPHCs) across 48 wards and 7 zones of the city. Study also involved healthcare workers (HCWs) from COVID-19/non-COVID-19 hospitals. INTERVENTIONS: Seropositivity of IgG antibodies against SARS-CoV-2 was measured as a mark of COVID-19 infection. PRIMARY AND SECONDARY OUTCOMES: Seropositivity was used to calculate cumulative incidence. Correlation of seropositivity with available demographic detail was used for valid and precise assessment of the pandemic situation. RESULTS: From 30 054 samples, the results were available for 29 891 samples and the crude seropositivity is 17.61%. For all the various age groups, the seropositivity calculated between 15% and 20%. The difference in seropositivity for both the sex group is statistically not significant. The seropositivity is significantly lower (13.64%) for HCWs as compared with non-HCWs (18.71%). Seropositivity shows increasing trend with time. Zone with maximum initial cases has high positivity as compared with other zones. UPHCs with recent rise in cases are leading in seropositivity as compared with earlier and widely affected UPHCs. CONCLUSIONS: The results of serosurveillance suggest that the population of Ahmedabad is still largely susceptible. People still need to follow preventive measures to protect themselves till an effective vaccine is available to the people at large. The data indicate the possibility of vanishing immunity over time and need further research to cross verify with scientific evidences.

GALAXY STRUCTURE, STELLAR POPULATIONS, AND STAR FORMATION QUENCHING AT 0.6 ≲ z ≲ 1.2.

We use both photometric and spectroscopic data from the Hubble Space Telescope to explore the relationships among 4000 Å break (D4000) strength, colors, stellar masses, and morphology, in a sample of 352 galaxies with log(M */M ⊙) > 9.44 at 0.6 ≲ z ≲ 1.2. We have identified authentically quiescent galaxies in the UVJ diagram based on their D4000 strengths. This spectroscopic identification is in good agreement with their photometrically-derived specific star formation rates (sSFR). Morphologically, most (that is, 66 out of 68 galaxies, ~ 97 %) of these newly identified quiescent galaxies have a prominent bulge component. However, not all of the bulge-dominated galaxies are quenched. We found that bulge-dominated galaxies show positive correlations among the D4000 strength, stellar mass, and the Sérsic index, while late-type disks do not show such strong positive correlations. Also, bulge-dominated galaxies are clearly separated into two main groups in the parameter space of sSFR vs. stellar mass and stellar surface density within the effective radius, Σe, while late-type disks and irregulars only show high sSFR. This split is directly linked to the 'blue cloud' and the 'red sequence' populations, and correlates with the associated central compactness indicated by Σe. While star-forming massive late-type disks and irregulars (with D4000 < 1.5 and log(M */M ⊙) ≳ 10.5) span a stellar mass range comparable to bulge-dominated galaxies, most have systematically lower Σe ≲ 109 M ⊙kpc-2. This suggests that the presence of a bulge is a necessary but not sufficient requirement for quenching at intermediate redshifts.