Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease.

OBJECTIVE: Type 1 diabetes (T1DM) is associated with other autoimmune diseases (AIDs), which may have serious health consequences. The epidemiology of AIDs in T1DM is not well defined in adults with T1DM. In this cross-sectional cohort study, we sought to characterize the incident ages and prevalence of AIDs in adults with T1DM across a wide age spectrum. RESEARCH DESIGN AND METHODS: A total of 1,212 adults seen at the Washington University Diabetes Center from 2011 to 2018 provided informed consent for the collection of their age, sex, race, and disease onset data. We performed paired association analyses based on age at onset of T1DM. Multivariate logistic regression was used to evaluate the independent effects of sex, race, T1DM age of onset, and T1DM duration on the prevalence of an additional AID. RESULTS: Mean ± SD age of T1DM onset was 21.2 ± 14.4 years. AID incidence and prevalence increased with age. Female sex strongly predicted AID risk. The most prevalent T1DM-associated AIDs were thyroid disease, collagen vascular diseases, and pernicious anemia. T1DM age of onset and T1DM duration predicted AID risk. Patients with late-onset T1DM after 30 years of age had higher risks of developing additional AIDs compared with patients with younger T1DM onset. CONCLUSIONS: The prevalence of AIDs in patients with T1DM increases with age and female sex. Later onset of T1DM is an independent and significant risk factor for developing additional AIDs. Individuals who are diagnosed with T1DM at older ages, particularly women, should be monitored for other autoimmune conditions.

Capturing Re(i) in an neutral N,N,N pincer Scaffold and resulting enhanced absorption of visible light.

The organometallic and coordination chemistry of rhenium(i) has been largely restricted to bidentate α-diimine ligation and facial tricarbonyl coordination geometries. The thermal transformation of bidentate bis(imino)pyridine and bidentate terpyridine complexes at 200-240 °C under nitrogen led to a family of Re(i) pincer complexes [κ(3)-2,6-{ArN[double bond, length as m-dash]CMe}2(NC5H3)]Re(CO)2X (Ar[double bond, length as m-dash]C6H5, Me2C6H3, (i)Pr2C6H3; X = Cl, Br) and (κ(3)-terpy)Re(CO)2X (X = Cl, Br). The synthesis, single crystal X-ray structural and spectroscopic characterization of these eight species documents their Re coordination geometries and demonstrates the accessibility of such compounds. The basic photophysical features of these compounds show significant elaboration in both number and intensity of the d-π* transitions observed in the UV-vis spectra relative to the bidentate starting materials and these spectra were analyzed using time-dependent DFT computations.