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Ann Med Interne (Paris) ; 153(3 Suppl): 1S20-6, 2002 May.
Artigo em Inglês | MEDLINE | ID: mdl-12218879

RESUMO

The purpose of this study was to analyze the impact of high-dose buprenorphine substitution therapy in opiate-dependent patients in terms of use of psychoactive substances, associated risks, social integration, and the social cost generated by the use of these substances. This was a longitudinal quantitative survey carried out in 1083 patients who were evaluated at three times: at the beginning of substitution therapy (D0), at 6 months and then at 12 months follow up (M6, M12). Data were collected with an anonymous self-administered questionnaire, completed in the presence of an investigating physician. Results demonstrated that patients treated with high-dose buprenorphine for 6 months, consumed fewer psychoactive drugs (heroin, cocaine, benzodiazepines) and had fewer associated risks. Additionally, several criteria involved in social integration showed improvement; morbidity and mortality decreased after the first 6 months of substitution therapy. These improvements were followed by a reduction in the social cost of drug use generated by the group of patients considered. These initial results require confirmation in the final analysis of the study taking into account the 12-month follow up.


Assuntos
Buprenorfina/economia , Buprenorfina/uso terapêutico , Efeitos Psicossociais da Doença , Antagonistas de Entorpecentes/economia , Antagonistas de Entorpecentes/uso terapêutico , Transtornos Relacionados ao Uso de Opioides/economia , Transtornos Relacionados ao Uso de Opioides/reabilitação , Comportamento Social , Adolescente , Adulto , Buprenorfina/administração & dosagem , Relação Dose-Resposta a Droga , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Morbidade , Mortalidade , Antagonistas de Entorpecentes/administração & dosagem , Psicotrópicos/administração & dosagem , Fatores de Risco , Resultado do Tratamento
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