[Diagnostic clinical trial with allergen extract from Blomia tropicalis in allergic adults and healthy volunteers]. / Ensayo clínico diagnóstico con extracto alergénico de Blomia tropicalis en adultos alérgicos y voluntarios sanos.

BACKGROUND: There are no antecedents in Cuba of studies developed to prove the efficacy of an allergy test to Blomia tropicalis despite of being one of the main mites which cause this ailment which affects more than 2,200,000 people. OBJECTIVES: Evaluate the allergenic extract Blomia tropicalis elaborated at the Centro Nacional de Biopreparados (BioCen), in the prick skin test, as a diagnose of allergy to this allergen which exists in all the tropical and subtropical countries. MATERIAL AND METHODS: We selected 50 patients with a positive clinic history of allergy to house dust and 50 healthy persons. Al the persons selected were skin prick tested with dilution's of the extracts (20,000 UB/mL) and positive and negative control. We measured the average diameter of the wheal and the perpendicular diameter, then we calculated the average. We also calculated size of the wheal in the duplicated, which constituted the size of the reaction. We estimated the validity of the test calculating the sensitivity and specificity. We used the EPITABLE program to do this. RESULTS: The skin prick tested positive in 78% of the patients and 6% in the healthy persons, for a sensitivity of 78% the interval of confidence (IC) 63.7-88.0 and a specificity of 94%, IC 82.5-98.4 the predictive negative value 81%, IC 68.2-89.7. CONCLUSIONS: The allergenic extract of Blomia tropicalis elaborated in BioCen is very sharp to test the allergy to this mite.

[Gastroesophageal reflux and allergic bronchial asthma. Controlled study]. / Reflujo gastroesofágico en asma bronquial alérgica. Estudio controlado.

BACKGROUND: The association between bronchial asthma and gastroesofageal reflux provokes in the patient a reserved prognostic which if not diagnosed and treat correctly, if interferes of significative in the life quality. MATERIAL AND METHOD: With the purpose of establishing a relation between the allergic bronchial asthma of the adult, patient with digestive symptoms and healthy volunteer, is carried out a study in 162 subject with these characteristics to whom an barium esophagography was done looking for gastroesofageal reflux. RESULTS: The reflux presence in the asthmatics are of 87.23% and in the patient with digestive upsets, 39.53%, ratio odds (OR), 10-43, confidence interval (IC) of 95%, 3.38-33.83. With relation to the healthy volunteers the OR is in 11.48, IC of 95% 3.93-35.22. Among the patients with digestive upsets and the healthy volunteers the OR is of 1.10, IC of 95%, 0.68-1.64. CONCLUSIONS: The gastroesofageal reflux in the patient with bronchial asthma allergic associated to digestive sintomatology prevails more than in patient with digestive symptoms similar the asthmatics, but without bronchial asthma and also more than in the healthy volunteers.