[Quality guidelines for radiopharmacy: Development of a risk-assessment tool]. / Référentiel qualité en radiopharmacie : création d'un outil d'analyse des risques.

OBJECTIVES: The medical management of patients, which involves securing the drug circuit, is a major public health objective. As part of quality management, a number of risk assessment and risk management tools in care units are validated and available. However, medication management in radiopharmacy departments represents a complex and specific process. The aim of the "Quality guidelines for radiopharmacy" working group of the French society of radiopharmacy (SoFRa) was to develop a risk-assessment tool that is a priori adapted to radiopharmacy activity. METHODS: A qualitative risk matrix was developed, based on available analysis tools and current regulations concerning radiopharmacy practice. The tool was then programmed to obtain a summary and scoring for each risk category, as well as a quantitative analysis of the risks identified in radiopharmacy. RESULTS: Our tool contains 262 issues. The qualitative study integrates the risks related to the circuit of radiopharmaceuticals, but also risks related to personnel. The quantitative study makes it possible to carry out an automated analysis of the actions to carry out in priority to improve the practices. CONCLUSIONS: This work led to the development of a self-assessment tool for the a priori analysis of risks that are adapted to the practice of radiopharmacy. It allows easy analysis of the entire circuit of radiopharmaceuticals from a single tool and meet the expectations of health authorities. This common and validated tool is available to the pharmaceutical community.

Mie scattering of magnetic spheres.

The Mie scattering intensity of a magnetic sphere has been derived by extending the classical Mie scattering approach to a media where the dielectric constant is no more a real number but a tensor with a gyrotropic form. Using a perturbation method the propagation equations of the electromagnetic field are derived. For an incident plane wave the magnetization effect could be detectable. The Mie scattering intensity is analyzed for special incident wave configurations, in particular, for the case where the magnetic field of the incident plane wave is polarized along the magnetization direction. This magnetization effect is most important for the finger pattern of the backscattering intensity. Magnetic Mie scattering is still significant for a magnetic sphere of radius larger than 10 nm.