RESUMO
OBJECTIVE: In this study, we aimed to discuss the clinical significance of CD4+CD25hiCD127low regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC). METHODS: Sixty patients with NSCLC and 35 healthy controls were studied. Peripheral blood CD4+CD25hiCD127lowTregs, CD4+CD25hiT cells, and CD4+T cells were measured with flow cytometric analysis, and results were compared between the groups. RESULTS: Compared with healthy people, CD4+CD25hiCD127low Tregs and CD4+CD25hi T cells significantly increased in patients with NSCLC, while CD4+ T cell proportions decreased. CONCLUSIONS: CD4+CD25 hi CD127low Treg detection in the peripheral blood of NSCLC patients is highly significant, in that it provides additional knowledge to guide the selection of individualized treatment plans for patients with NSCLC.