RESUMO
BACKGROUND: To report two cases of eyelash loss in Frontal Fibrosing Alopecia, providing microscopic description of the eyelashes and possible association with Demodex folliculorum. CASE PRESENTATION: We present two cases of postmenopausal women diagnosed with frontal fibrosing alopecia who consulted the ophthalmology department for eyelid itching and eyelash loss. On examination, there were no signs of blepharitis, but loss of lashes was observed, and the remaining eyelashes detached easily from the eyelid. The eyelashes were examined microscopically. The bulbs were small and narrow, and the caliber of the lashes was irregular, with thinner and thicker areas. The pigment distribution was irregular; there were portions with greater or lesser accumulation. In the second case, clusters of Demodex folliculorum were observed near the eyelash root. CONCLUSION: This is the first microscopic description of eyelash loss in frontal fibrosing alopecia in the published literature. We describe small, narrow bulbs, irregular caliber of the eyelashes and irregular pigment distribution. In the second case, in which we found Demodex folliculorum infestation, there was eyelash loss even though the disease was not very advanced. We suggest that there might be an association whereby Demodex infestation might accelerate autoimmune inflammation, leading to premature eyelash loss.
Assuntos
Blefarite , Pestanas , Infestações por Ácaros , Alopecia/diagnóstico , Feminino , Humanos , InflamaçãoRESUMO
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Assuntos
Humanos , Feminino , Adulto , Doenças do Colágeno/diagnóstico , Doenças do Colágeno/genética , Doenças do Colágeno/patologia , Dermatoses da Mão/etiologia , Dermatoses da Mão/terapia , Dermatoses da Mão/genética , Ceratose/patologiaAssuntos
Doenças do Colágeno/patologia , Dermatoses da Mão/patologia , Dermatopatias Papuloescamosas/patologia , Adulto , Doenças do Colágeno/complicações , Doenças do Colágeno/genética , Feminino , Dermatoses da Mão/complicações , Dermatoses da Mão/genética , Humanos , Dermatopatias Papuloescamosas/complicações , Dermatopatias Papuloescamosas/genéticaRESUMO
A newborn female experienced severe respiratory distress immediately after delivery. She presented with intense cyanosis, refractory hypoxemia, and acidosis. The deterioration was rapidly progressive, leading to the child's demise. The autopsy showed common pulmonary vein atresia, the most severe form of pulmonary venous drainage obstruction. Subpleural and interstitial pulmonary lymphagiectasias also were present as well as evidence of pulmonary hypertension. The lung pathology probably resulted from pulmonary venous atresia during prenatal development.
