Association of Serum Triglycerides and Total Cholesterol Levels with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh.

Impaired fasting glucose (IFG) is known as an intermediate state in the development of diabetes mellitus. It may be considered as a potential indicator for prevention of diabetes mellitus (DM) and cardiovascular diseases (CVDs). Dyslipidemia is characterized by high or low level of triglycerides and total cholesterol. It is known that, triglycerides and total cholesterol level raises in the DM patients. An endeavor was taken in this study to show the relationship of triglycerides (TG) and total cholesterol (TC) with IFG. This cross-sectional analytical study was carried out in Biochemistry Department of Sir Salimullah Medical College, Dhaka, Bangladesh from March 2018 to February 2019 on 120 subjects. The study subjects were 25-55 years of age. Subjects were classified into two groups i.e., Normal fasting glucose (NFG) group and IFG group. Oral glucose tolerance test (OGTT) was performed from the collected blood. TG and TC levels were measured from serum. TG and TC levels were higher (p<0.01) in IFG group than NFG group (185.56±10.32 mg/dl vs. 137.9±10.3 mg/dl) and (194.74±19.96 mg/dl vs. 174.59±13.20 mg/dl) respectively. Pearson's correlation analysis shows significant positive correlation of FPG with TG (r=0.278, p= <0.01) and TC (r=0.105, p= <0.05) in IFG subjects. Multiple regression analysis of the relation between Fasting plasma glucose (FPG) with TG and TC by adjustment of other factors revealed that IFG was significantly (p<0.01) associated with TG and TC. The AUROCs of TG, TC for IFG was found to be 0.819 (95% CI: 0.745 - 0.893), 0.652 (95% CI: 0.553-0.751) with accuracy of 76.67% and 63.33% respectively.

Association of Obesity and Serum Gamma Glutamyl Transferase with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh.

Obesity is a worldwide health concern due to its rising tendency both in developing and developed countries. Obesity is known to be associated with a number of disorders including type 2 diabetes mellitus, hypertension and cardiovascular diseases. Gamma glutamyl transferase (GGT) is synthesized in liver. GGT is considered as an oxidative stress marker. Serum GGT is increased in patients with cardiovascular diseases and diabetes mellitus (DM). Impaired fasting glucose (IFG) is a risk factor for cardiovascular diseases. The aim of this study was to find out the association of obesity and serum GGT with IFG. This cross-sectional analytical study was conducted in the Biochemistry department of Sir Salimullah Medical College, Dhaka from March 2018 to February 2019. The ages of the subjects were 25-55 years. The study subjects were 120 and were divided into two groups. The groups were Normal fasting glucose (NFG) group and IFG group according to WHO diagnostic criteria. Body mass index (BMI) was used as a measure of general obesity and waist circumference (WC) and waist-hip ratio (WHR) were used as measures of abdominal or central obesity. OGTT was performed from collected blood. GGT and lipid profile were measured from serum. In IFG group, BMI, WC, WHR and GGT levels were significantly elevated (p<0.01) than NFG group i.e. BMI (22.70±1.35 vs. 28.37±2.33kg/m²), WC (79.96±5.31 vs. 93.42±4.21cm), WHR (0.92±0.06 vs. 0.97±0.07), and GGT (24.19±8.41 vs. 67.23±14.40U/L). Fasting Plasma Glucose (FPG) level were significantly higher (p<0.01) in obese group than over weight and normal BMI groups 4.70±0.08, 5.30±1.3 and 6.50±0.3 respectively. FPG were higher in male and female obese group than normal WC group (4.8±1.1 vs. 6.3±0.60mmol/L) and (4.4±0.7 vs. 6.2±0.80mmol/L). Odds Ratio (OR) and (95% CI) for IFG were 6.53 and 21.0 with BMI tertile 2(23.1- 27.5kg/m²) and tertile 3(≥27.5kg/m²) where T1 (<23.0kg/m²) was considered as reference category. OR for IFG were 4.1 and 20.25 with GGT tertile 2(24.0-42.0) U/L and tertile 3(>42.0) U/L where T1 (<24.0) U/L was considered as reference category. Multiple regression analysis shows positive correlation of FPG with BMI, WC, WHR and GGT.

Association of Serum Uric Acid Level with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh.

Impaired fasting glucose (IFG) is a vital risk factor for overt diabetes. Increased serum uric acid (UA) may reflect systemic inflammation and oxidative stress. Insulin secretion by pancreatic ß cells is impaired due to oxidative stress. Serum UA levels are elevated in patients with diabetes or cardiovascular disease. The aim of this study was to explore the relationship between serum UA and impaired fasting glucose (IFG). This cross-sectional analytical study was conducted on 120 subjects aged 25-55 years in the department of Biochemistry of Sir Salimullah Medical College, Dhaka, Bangladesh from March 2018 to February 2019. The study subjects were divided into two groups with either normal fasting glucose (NFG) or impaired fasting glucose (IFG) according to WHO diagnostic criteria. Blood was collected to perform OGTT. Serum was separated to measure UA. Serum UA levels were significantly higher (p<0.01) in IFG group than NFG group (7.61±1.31 vs. 4.84±1.27). Odds Ratio (OR) for IFG were 2.05 and 17.69 with UA tertile 2 (5.7-7.5) mg/dl and tertile 3 (>7.5) mg/dl where T1 (<5.7) mg/dl was considered as reference category. Multiple regression analysis of the relation between fasting plasma glucose (FPG) and serum UA by adjustment of other factors revealed that IFG was significantly (p<0.05) associated with serum UA.

Association of Serum Gamma Glutamyl Transferase and Uric Acid Levels with Impaired Fasting Glucose in Adults at a Tertiary Level Hospital of Bangladesh.

Impaired fasting glucose (IFG) is an important risk factor for overt diabetes. Gamma glutamyl transferase (GGT) is an oxidative stress maker that is synthesized in liver. Increased serum Uric Acid (UA) may reflect systemic inflammation and oxidative stress. Insulin secretion by pancreatic ß cells is impaired due to oxidative stress. Serum GGT and UA levels are elevated in patients with diabetes or cardiovascular disease. The aim of this study was to explore the relationship between serum GGT and UA with IFG. This cross-sectional study was conducted on 120 subjects aged 25-55 years. The study subjects were divided into two groups with either Normal fasting glucose (NFG) or IFG according to WHO diagnostic criteria. Blood was collected to perform OGTT. Serum was separated to measure GGT, UA and lipid profile. GGT and UA levels were significantly higher (p<0.01) in IFG group than NFG group (67.23±14.40 vs. 24.19±8.41) and (7.61±1.31 vs. 4.84±1.27). Odds Ratio (OR) for IFG were 4.1 and 20.25 with GGT tertile 2 (24.0-42.0) U/L and tertile 3 (>42.0) U/L where T1 (<24.0) U/L was considered as reference category. Odds Ratio (OR) for IFG were 2.05 and 17.69 with UA tertile 2 (5.7-7.5)mg/dl and tertile 3(>7.5) mg/dl where T1 (<5.7)mg/dl was considered as reference category. Multiple regression analysis of the relation between Fasting plasma glucose (FPG) with serum GGT and UA by adjustment of other factors revealed that IFG was significantly (p<0.01) associated with serum GGT and UA.