1.
J Org Chem
; 85(16): 10951-10957, 2020 08 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32677438
RESUMO
Two methods for the determination of pKa values of weak acids are described, a direct titration with dimsyl potassium in the presence of an indicator and a back-titration in which an analyte/indicator mixture is deprotonated and then titrated with ammonium chloride. Both methods have been validated by measuring pKa values of compounds, for which values had been determined previously. The back-titration method was applied to measure pKa values of two 1,3-dithiane-derived bissulfoxides and a monosulfone.