Antiandrogens in the treatment of acne and hirsutism.

Antiandrogens have been found to be effective in the treatment of acne and hirsutism. Cyproterone acetate has been used in Europe for many years, but in the United States it has only been approved as an orphan drug to treat severe hirsutism. Spironolactone is approved in the United States for its antialdosterone effect but not for its antiandrogenic effect, although it is widely used for the latter purpose. While cyproterone is a more effective drug than spironolactone, it is more likely to produce undesirable side effects.

Plaque-type intertriginous cutaneous calcification.

Cutaneous calcification is classified into four types: dystrophic, idiopathic, tumoral, and metastatic. We present a patient with systemic lupus erythematosus undergoing hemodialysis who noted large plaque-like cutaneous calcifications in the axillae and groin. Some plaques occurred in association with striae related to prior corticosteroid therapy for the patient's underlying systemic disease. This case is unusual because of the clinical presentation, its demonstration of both dystrophic and metastatic types of calcification, and histologic calcification of elastic fibers simulating pseudoxanthoma elasticum.