Assessment of PFA-100 system for the measurement of bleeding time in oral surgery.

UNLABELLED: The common diagnostic methods to know primary hemostasis have been classified as invasive, depending on the operator, difficult to reproduce and at times not very reliable. Thus, different systems have been proposed to assess bleeding time, one of them being the PFA-100 device, which we present in this paper. OBJECTIVE: Compare specificity between the traditional Ivy method with the PFA-100 system to measure bleeding time. MATERIAL AND METHOD: We obtained a sample of 33 patients between the age of 24-80 years receiving anti-platelet treatment who needed to undergo oral surgery. Bleeding time was obtained by the Ivy method, an INR by an analysis done on the same day and a Coagucheck one hour before surgery as well as measurement of bleeding time with the PFA-100 system. RESULTS: Mean value of bleeding time through the Ivy method was 406.36 sec.. Mean bleeding time with the PFA-100 system for the collagen/epinephrine cartridge was 226.91 sec. and for the collagen/ADP cartridge was 110.27 sec.. All these values were within normality. We observed very high standard deviations with the Ivy method and more regular ones for the PFA-100 system, indicating its greater specificity. We also obtained a large correlation between collagen/epinephrine cartridge and acetylsalicylic acid. CONCLUSIONS: We found greater specificity of the analyzer of PFA-100 platelet function for the measurement of bleeding time in relationship with the traditional Ivy method.

Assessment of PFA-100 system for the measurement of bleeding time in oral surgery

Los métodos diagnósticos habituales para conocer la hemostasia primaria han sido calificados como cruentos, dependientesdel operador, de difícil reproducción y en ocasiones no muy fiables. Es por ello que se han propuesto diferentes sistemas para valorar el tiempo de hemorragia, siendo uno de ellos el dispositivo PFA-100, el cual presentamos en este trabajo.Objetivo: Comparar la especificidad entre el método tradicional Ivy con el sistema PFA-100 para la determinación del tiempo de hemorragia.Material y método: Obtuvimos una muestra de 33 pacientes de entre 24-80 años en tratamiento antiplaquetario a los cuales se debía realizar una cirugía oral. Se les realizó un tiempo de hemorragia mediante el método Ivy , un INR medianteuna analítica realizada el mismo día y un Coagucheck una hora antes de la cirugía así como la determinación del tiempo de sangrado mediante el dispositivo PFA-100. Resultados: El valor medio del tiempo de hemorragia mediante el método Ivy fue de 406.36 sg. El tiempo de hemorragia medio con el sistema PFA-100 para el cartucho de colágeno/epinefrina fue de 226.91 sg. y para el cartucho de colágeno/ADP fue de 110.27 sg. Todos estos valores se encuentran dentro de la normalidad. Observamos desviaciones típicas muy altas con el método Ivy y más regulares para el sistema PFA-100 indicando una mayor especificidad del mismo. Obtuvimos también una gran correlación entre el cartucho colágeno/epinefrina y el ácido acetil salicílico.Conclusiones: Encontramos una mayor especificidad del analizador de función plaquetaria PFA-100 para la medición del tiempo de hemorragia en relación con el método tradicional Ivy

The common diagnostic methods to know primary hemostasis have been classified as invasive, depending on the operator, difficult to reproduce and at times not very reliable. Thus, different systems have been proposed to assess bleeding time, one of them being the PFA-100 device, which we present in this paper.Objective: Compare specificity between the traditional Ivy method with the PFA-100 system to measure bleeding time.Material and method: We obtained a sample of 33 patients between the age of 24-80 years receiving anti-platelet treatment who needed to undergo oral surgery. Bleeding time was obtained by the Ivy method, an INR by an analysis done on the same day and a Coagucheck one hour before surgery as well as measurement of bleeding time with the PFA-100 system.Results: Mean value of bleeding time through the Ivy method was 406.36 sec.. Mean bleeding time with the PFA-100 system for the collagen/epinephrine cartridge was 226.91 sec. and for the collagen/ADP cartridge was 110.27 sec.. All these values were within normality. We observed very high standard deviations with the Ivy method and more regular ones for the PFA-100 system, indicating its greater specificity. We also obtained a large correlation between collagen/epinephrine cartridge and acetylsalicylic acid.Conclusions: We found greater specificity of the analyzer of PFA-100 platelet function for the measurement of bleeding time in relationship with the traditional Ivy method