Evaluation of the intraocular pressure changes during micturition in patients with benign prostatic hyperplasia.

OBJECTIVE: To evaluate the effect of the Valsalva maneuver (VM) during micturition on intraocular pressure (IOP) in patients with benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: IOP were measured before and during micturition in uroflowmetry testing by Tonopen-Avia (Reichert Inc., NY, USA) in 35 eyes of 35 patients with BPH. International Prostate Symptoms Score (IPSS) questionnaire was used for quantification of BPH symptoms. The subjects were divided into two groups according to IPSS questionnaire: patients with low IPSS scores and patients with high IPSS scores. RESULTS: The mean IOP before and during micturition in patients with BPH were 15.26 ± 4.39 mmHg and 16.23 ± 4.43 mmHg, respectively (p = 0.047). When patients with BPH were assigned to two distinct groups according to the IPSS scores, IOP did not differ in patients with low IPSS scores (p = 0.590), whereas mean IOP was significantly higher in patients with high IPSS scores (p = 0.007). CONCLUSIONS: The Valsalva maneuver, performed during micturition, can lead to significant IOP increase in patients with BPH, particularly in advanced disease.

Biochemical and biomechanical assessment of effects of L-carnitine on oral mucosal wounds.

OBJECTIVES: The present study aimed to investigate the oral mucosal wound healing potential of L-carnitine in a rat model. MATERIALS AND METHODS: Twenty-four Wistar-albino rats were divided into 4 groups: control group (group I), L-carnitine groups (100 and 200 mg/kg/day, intraperitoneally) (groups II and III), and vitamin E group (100 mg/kg/day, intraperitoneally) (group IV). A 1.5-cm linear incision was created on the buccal mucosa of each rat and was left to heal by secondary intention. On the tenth day, rats were anesthetized and sacrificed. The tensile strength of wound was measured with a tensiometer. Hydroxyproline (HYP) and malondialdehyde (MDA) levels in wound were assayed by spectrophotometry. Results were statistically analyzed using a one-way ANOVA analysis (p ≤ 0.001). RESULTS: In the analysis of tissue samples, there was a statistically significant decrease in MDA levels in group II (p < 0.01) and group IV (p < 0.001). Wound tension strength that was seen in groups II (57.88 %) and IV (48.71 %) was better than group III (33.39 %). Hydroxyproline levels in group II (46.98 ± 1.37) was higher than groups III (29.40 ± 1.64) and IV (38.83 ± 1.41). CONCLUSION: Although there was a tendency toward faster healing in the groups receiving L-carnitine, it may have a dose-related positive effect for wound healing. CLINICAL RELEVANCE: With the advantages of having positive effects on wound healing, being a natural substance in the body, being easy to procure, and having a practical usage, L-carnitine may be clinically feasible for human oral mucosal wounds.

Craniofacial growth and skeletal maturation: a mixed longitudinal study.

The purpose of this study was to investigate the relationship between craniofacial growth and skeletal maturation. The material consisted of the cephalometric and hand-wrist film pairs of 35 males and 43 females (78 subjects) whose development was followed for a period of 4 to 7 years. The subjects were grouped according to their skeletal maturation. Their mean ages were: Group I 10.27, Group II 11.55, and Group III 14.79 years, respectively, at the beginning of the observation period. Intra- and inter-group differences were examined through paired t-tests, and Pearson correlation analysis was used to detect the relationship between craniofacial growth and skeletal maturation (percentage growth potential). The results show that the middle cranial base (T-W) maintained its stability in all pubertal growth periods. However, posterior cranial base length (T-Ba) increases significantly (P < 0.001) throughout the same period. There were similar increases in the vertical dimensions of the face and alveolar height throughout pubertal growth. Despite the intensified increases in both the sagittal and vertical directions, facial characteristics were constant in the sagittal direction. The skeletal development (percentage growth potential) has clearly been effective in the vertical facial development commencing in Group I and reaching its maximum level in Group II. However Cd-Go was the exception.

Extracranial versus intracranial references in individual cephalometric analysis.

This study was undertaken to determine whether angles SNA and ANB genuinely represent both the degree of maxillary prognathism and the intermaxillary relationship in natural head position (NHP). Pearson's r correlation coefficients were used to assess the associations between these angles, and variables based on NHP and extracranial reference lines. A large sample (n = 106) was used, comprising subjects with a variety of facial patterns. This was also divided into subgroups comprising subjects with similar facial configurations, determined by natural head position parameters. For the subgroups, SNA and ANB were not associated with the variables based on NHP, and showed high variations in subjects with similar facial patterns. SNA also showed statistically significant and high correlation with the inclination of the NSL to the true vertical.

Natural cervical inclination and craniofacial structure.

The purpose of this study was to search for the statistical associations between postural and morphologic variables of the head. Interpretation of the facial structure was made by using both intracranial and the extracranial reference lines. The sample comprised natural head posture (NHP) cephalograms of 106 dental students, aged 19 to 29 years. Results showed that, when the facial structure was evaluated by using a NHP analysis based on extracranial reference lines, it was associated with the inclination of the cervical column to the true horizontal. In addition, in the natural position of the head, inclination of the NSL reference was found to be associated with the vertical localization of sella turcica (r = -724, p < or = 0.001), rather than the "extension" or "flexion" of the head. It was concluded that associations between posture and structure of the head are merely caused by the functional factors related to "forward cervical posture" and "vertical cervical posture".

[Prediction of mandibular growth rotation]. / Mandibula büyüme modelinin tahmini.

Growth of the facial skeleton and prediction of the mandibular rotation has been subjected to a great number of studies in recent years. For prediction of the mandibular growth rotation, mandibular plane inclination in relation to the cranial base has been used frequently for many years. On the other hand, besides individual variability, statistical studies have also implied that the mandibular inclination in relation to the cranial base can be considered as a morphogenetic feature, which reflects the actual growth rotation pattern of the mandible only to a moderate degree. Thus, for a better prediction of mandibular growth rotation, some other features have to be used together with the mandibular plane inclination.