RESUMO
PURPOSE: To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD). PATIENTS AND METHODS: This case-control study included a total of 120 patients with AMD (65 with dry-type AMD and 55 with wet-type AMD) and 198 disease-free controls. GSTM1 and GSTT1 polymorphisms were analyzed by using a multiplex polymerase chain reaction (PCR), and GSTP1 polymorphism was detected by real-time PCR assay. RESULTS: GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.82, 95% CI = 1.14-2.91). Stratification by AMD subtypes revealed a significant relationship between GSTM1-null genotype and dry-type AMD (p = 0.02, OR = 1.98, 95% CI = 1.10-3.53). In a stepwise regression model, only GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.77, 95% CI = 1.11-2.81). CONCLUSIONS: Our findings suggest that genetic polymorphisms of GST may have a role in the development of AMD.
Assuntos
Atrofia Geográfica/genética , Glutationa S-Transferase pi/genética , Glutationa Transferase/genética , Polimorfismo Genético , Degeneração Macular Exsudativa/genética , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Angiofluoresceinografia , Genótipo , Atrofia Geográfica/diagnóstico , Humanos , Verde de Indocianina , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Fatores de Risco , Degeneração Macular Exsudativa/diagnósticoRESUMO
The authors describe the anterior segment optical coherence tomography (AS-OCT) findings of a 25-year-old patient with acute hydrops associated with keratoconus. The patient presented with decreased visual acuity, pain, and redness in the left eye. The symptoms, clinical presentation, and topographical findings of the right eye confirmed this condition to be acute corneal hydrops. The patient was closely followed up with hyper-osmotic (NaCl 5%) and nonsteroidal anti-inflammatory (ketorolac tromethamine 0.5%) topical treatment. At the initial examination and during follow-up, the evaluation of the anterior segment was performed using optical coherence tomography. Changes in the stroma and Descemet's membrane during the healing process of acute hydrops could be demonstrated by high-resolution AS-OCT.
Assuntos
Segmento Anterior do Olho/patologia , Edema da Córnea/diagnóstico , Edema da Córnea/etiologia , Ceratocone/complicações , Tomografia de Coerência Óptica , Doença Aguda , Adulto , Humanos , MasculinoRESUMO
PURPOSE: To present fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and microperimetry (MP) findings of a patient with multiple evanescent white dot syndrome (MEWDS). METHODS: Observational case report. RESULTS: A 30-year-old woman with blurry vision was referred for evaluation. Fundus examination revealed only foveal granularity. FAF showed hyperautofluorescent spots, although they were not visible clinically. On ICGA, matching areas were hypofluorescent. Microperimetry revealed mean sensitivity decrease. The resolution of the symptoms was followed by disappearance of these spots in FAF and ICGA and increase of mean macular sensitivity in MP. CONCLUSION: FAF is a noninvasive imaging technique that might help in the differential diagnosis of chorioretinal pathologies.
