Long-term outcomes of transcanalicular laser dacryocystorhinostomy versus endonasal dacryocystorhinostomy and a review of the literature.

Objective: The aim of this study was to compare the efficacy of endonasal dacryocystorhinostomy (EDCR) compared with transcanalicular laser DCR (TL-DCR). Materials and Methods: This retrospective study and systematic review included patients that underwent DCR for nasolacrimal duct obstruction at our tertiary academic care hospital between January 2013 and December 2017. TL-DCR and EDCR were performed on 42 (group 1) and 45 (group 2) patients, respectively. All patients were followed up for a minimum of 4 years after DCR. Success was defined as the complete disappearance of epiphora and the observation of fluid flow without any anatomic obstruction during lacrimal system irrigation. Results: This study included 87 patients who underwent DCR. Fourteen patients (18.7%) were male, and 61 (81.3%) were female. Groups 1 and 2 consisted of 42 and 45 patients who underwent TL-DCR and EDCR, respectively. Success was achieved by 78.5% and 84.4% in groups 1 and 2, respectively. Patients in both groups were followed up for at least 4 years. There was a significant difference in mean surgery time between groups: 33.8 ± 10.5 min vs. 69.9 ± 15.9 min for groups 1 and 2, respectively (P < 0.001). Conclusion: EDCR and TL-DCR without silicone stent have offered a high success rate in the long term. Furthermore, endonasal procedures have less surgery time and leave no scar. We observed that EDCR and TL-DCR are favorable methods in cases of nasolacrimal duct obstruction.

Evaluation of the change in accommodation amplitude in subjects with pseudoexfoliation.

PURPOSE: To evaluate the changes in accommodation amplitude in cases with pseudoexfoliation. MATERIALS AND METHODS: Twenty-nine eyes having pseudoexfoliation and 37 normal eyes aged between 40-60 years were included in the study. After ophthalmic examination, accommodation amplitude was measured using Powerrefractor II. Besides, axial length, anterior chamber depth, and lens thickness was measured by A-scan ultrasonography. The results obtained were evaluated by independent samples' t-test. RESULTS: There was no difference in mean age between cases with pseudoexfoliation and normal cases (P=0.131). Mean accommodation amplitude was significantly lower in cases with pseudoexfoliation (P=0.002). Axial length, anterior chamber depth, and lens thickness measurements did not show significant change between groups (P=0.55, P=0.66, P=0.36, respectively). CONCLUSION: In the presence of pseudoexfoliation, ciliary apparatus can be affected and accommodation amplitude can be decreased in earlier ages.

A new visual field test in empty sella syndrome: rarebit perimetry.

PURPOSE: Several visual field defects can be seen in empty sella syndrome (ESS). In this study, the authors aimed to evaluate the visual field defects in patients with ESS by rarebit perimetry and to compare the results with Humphrey perimetry. METHODS: Left eyes of 13 patients with ESS and left eyes of 15 age-matched normal subjects were included in the study. Visual field testing was performed by Humphrey Visual Field Analyzer II (Fastpack 30-2 strategy) and rarebit perimetry (regular test). Statistical analysis was performed by independent-samples t-test, Mann-Whitney U test, receiver operating characteristic (ROC) curves, and Pearson correlation test. RESULTS: Humphrey perimetry mean deviation was -3.67 dB in control group and -6.06 dB in patients with ESS (p=0.12). Mean hit rate calculated by rarebit test was 91.8% in control group and 75.9% in cases with ESS (p=0.005). Area under ROC curve was 0.756 for Humphrey visual field test and 0.827 for rarebit hit rate (p=0.59). There was a significant correlation between rarebit hit rate and Humphrey visual field test mean deviation (r=0.755, p<0.001). CONCLUSIONS: Rarebit perimetry correlates significantly with Humphrey perimeter in detecting visual field defects related with ESS and has a higher sensitivity and specificity.

The effect of levodopa and dopamine agonists on optic nerve head in Parkinson disease.

PURPOSE: To evaluate the effects of levodopa and dopamine agonists on retinal nerve fiber layer using scanning laser ophthalmoscope. METHODS: Forty-four patients with the diagnosis of Parkinson disease and receiving levodopa or dopamine agonist monotherapy were included in this prospective study. The control group consisted of 21 normal cases. The optic nerve head images were taken with Heidelberg Retina Tomograph; rim area, rim volume, mean retinal nerve fiber layer thickness, and the results of Moorfields regression analysis were calculated. The measurement results were evaluated with Kruskal Wallis test and Mann-Whitney U-test. RESULTS: There was no significant difference in mean age among groups (p=0.093). Retinal nerve fiber layer was measured to be significantly decreased in cases with Parkinson disease (p=0.004) while rim area and rim volume did not show a significant change (p=0.224, p=0.804 respectively). Rim area, rim volume, and retinal nerve fiber layer were significantly greater in the group treated with levodopa while it was the thinnest in the group receiving dopamine agonists. CONCLUSIONS: Levodopa can have a protective affect to retinal nerve fiber layer in Parkinson disease compared to dopamine agonists.

Keratoconus and Fuchs' heterochromic iridocyclitis: a coincidence or a defect during embryogenesis?

PURPOSE: We aimed to discuss the possible role of developmental embryologic factors in neural crest cells in the aetiology of keratoconus and Fuchs' heterochromic iridocyclitis by presenting this case. CASE REPORT: We diagnosed bilateral keratoconus and unilateral Fuchs' heterochromic iridocyclitis in a 19 year old women complaining of progressively blurring vision in her left eye. We also examined most of her first and second degree relatives. One niece had FHI in addition to a choroidal nevus in the inferior temporal quadrant of her left eye. DISCUSSION: Regarding the common embryological origins of iris stroma, uveal melanocytes and corneal stroma, it might be worth considering that the combination of FHI and keratoconus is not coincidental. A role of embryologic factors in neural crest cells in the etiology of both diseases cannot be excluded.