Intention and Monitoring Influence the Content of Memory Reports.

OBJECTIVES: While voluntary memories are intended and expected, involuntary memories are retrieved with no intention and are usually unexpected (when one is not waiting for a memory). The present study investigates the effects of retrieval intentionality (wanting to retrieve a memory) and monitoring processes (expecting a memory to appear) on the characteristics of autobiographical memories. METHODS: To this end, by applying mixed-method analysis of memory descriptions (i.e. combining qualitative with quantitative analyses) we re-analysed the large pool of involuntary and voluntary memories obtained in one previously published study, asking independent judges to rate all the memories on several dimensions reflecting memory accessibility (i.e. the likelihood that a memory can be retrieved). RESULTS: When discussing our findings, we speculate that there may be several stages of memory retrieval that might be differently influenced by intention and monitoring. CONCLUSIONS: We discuss the novel hypothesis that there may be two different types of monitoring that operate independently of each other, before and after retrieval, respectively.

Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease and Healthy Controls: A Cohort Study.

Gut microbiome and colonic inflammation can be associated with the predisposition and progression of Parkinson's disease (PD). The presented study aimed to compare gastrointestinal microbiota composition between patients diagnosed with PD and treated only with Levodopa to healthy controls. In this prospective study, patients were recruited in 1 academic hospital from July 2019 to July 2020. The detailed demographic data and medical history were collected using a set of questionnaires. Fecal samples were obtained from all participants. Next-Generation Sequencing was used to assess the microbiota composition. The endpoint was the difference in composition of the gut microbiota. In this study, we enrolled 27 hospitalized PD patients with well-controlled symptoms. The control group included 44 healthy subjects matched for age. Among PD patients, our results presented a higher abundance of Bacteroides phylum, class Corynebacteria among phylum Actinobacteria, class Deltaproteobacteria among phylum Proteobacteria, and genera such as Butyricimonas, Robinsoniella, and Flavonifractor. The species Akkermansia muciniphila, Eubacterium biforme, and Parabacteroides merdae were identified as more common in the gut microbiota of PD patients. In conclusion, the patients diagnosed with PD have significantly different gut microbiota profiles in comparison with healthy controls.