Towards eco-friendly biocides: preparation, antibiofilm activity of hemibastadin analogues.

The antibiofilm activity of three hemibastadins analogues was evaluated against different marine bacterial strains through mono-species biofilms and through a multi-species model of biofilm. Results showed that compound 3 exhibited interesting antibiofilm efficiencies effective concentrations (EC50 ) in the range of 30-100 µmol l-1 without acute toxicity against bacteria. Toxicity against nontargeted organisms was also considered showing that the compound did not affect the global bacterial community at a concentration of 75-100 µmol l-1 . These results provided baseline data concerning the toxicity of antibiofilm biocides against marine organisms. SIGNIFICANCE AND IMPACT OF THE STUDY: This study reports relevant information about antibiofilm activity of original derivatives of hemibastadin alkaloids. The most active compound was shown to act as a specific anti-biofilm inhibitor without affecting viability of the targeted bacteria no more than those of the global bacterial community of a seawater sample. Taken together, these findings indicate the potentiality of such compounds to be used as original nonbiocidal molecules for designing eco-friendly antifouling solutions.

Double ostéotomie tibiale pour maladie de Blount infantile négligée

Le traitement de la maladie de Blount infantile négligée est complexe. Une patiente avec une forme bilatérale a consulté à l'âge de 12 ans. Il a été réalisé pour chaque genou une double ostéotomie tibiale dans le même temps opératoire. Un délai d'un an séparait les deux interventions. Il s'agissait d'une ostéotomie épiphysaire de relèvement du plateau tibial interne et d'une ostéotomie de valgisation sous la tubérosité tibiale antérieure. Le vide créé par le relèvement a été comblé par les fragments tibial et péronier. Cette double ostéotomie tibiale était instrumentée. Au denier recul de cinq ans (à droite) et quatre ans(à gauche),la patiente était satisfaite avec de bons axes. Il n'y avait pas de raccourcissement

Résultats de la technique de Sauvé Kapandji dans les séquelles post-traumatiques du poignet

Introduction: L'intervention de Sauvé-Kapandji consiste à réaliser une arthrodèse radio-ulnaire distale associée à une pseudarthrose intentionnelle de l'ulna. Le but de cette étude était d'évaluer les résultats obtenus avec cette technique dans le traitement des désordres post-traumatiques du poignet. Matériels et méthodes: Cette étude rétrospective réalisée entre janvier 2005 et décembre 2014 a concerné huit patients. La lésion était une séquelle d'une fracture de Galéazzi (n=5) , un cal vicieux d'une fracture de l'extrémité inférieure du radius(n=2), et une arthrose post-traumatique du poignet(n=1). Tous les poignets étaient douloureux, avec limitation de la mobilité et restriction de la force de serrage de la main. Résultats: Au recul moyen de 16 mois (extrême 8 et 36 mois) la douleur a été soulagée chez six patients. La pronation moyenne a été améliorée de 46° à 75°, la supination de 51° à 77°, la flexion de 44,5° à.48°, et l'extension de 24° à 54°. L'angle d'inclinaison radiale moyen a été amélioré de 18° à 20°, l'angle d'inclinaison de la glène moyen de 9,75°à 12°, et l'index radio-ulnaire distale de + 3 mm à +1mm. La force de serrage a été satisfaisante chez six patients cas et mauvaise chez deux. Toutes les arthrodèses ont fusionné. Conclusion: La technique de Sauvé Kapandji a permis le soulagement de la douleur, le renforcement de la mobilité et de la force de préhension chez la majorité des patients

[Clinical and developmental aspects of care-related tetanus in the reference service of the teaching hospital of Abidjan]. / Aspects cliniques et évolutifs du tétanos lié aux soins dans le service de référence du CHU d'Abidjan.

A cross-sectional descriptive study was conducted from medical data of inpatients with tetanus in the Department of Infectious and Tropical Diseases of the University Hospital of Treichville in Abidjan from January 2003 to December 2007. In five years, 221 cases of tetanus have been hospitalized. The tetanus gateway was found in 188 patients (85%). Tetanus gateway linked to care was found in 22 patients (11.7%). Acts of care in question were intramuscular injections (10 cases) and operative procedures (12 cases). Concerning medical care by intramuscular injection, quinine (four cases), sulfadoxine-pyrimethamine (one case), and long-acting penicillin (one case) were the identified drugs. The operative procedures mainly involved were skin sutures (nine cases), cures of hernia (two cases), and flattening of Fournier's gangrene (one case). The average incubation period was 9.5 days. The invasion lasted for an average of 1.8 days. On admission, tetanus was immediately generalized for all patients with the presence of paroxysms in 20 patients (90.9%). The lethality of tetanus related care was 54.5%. The death rate in the first 48 hours of hospitalization was estimated at 83.3%. The average length of hospital stay was 14.6 days. Health workers should be involved in the prevention of tetanus in improving the quality of care and especially in reducing intramuscular injections. Also, any patient not immunized against tetanus should receive anti-tetanus serum and an update of its tetanus vaccine before any invasive procedures.

Oropharyngeal candidiasis in AIDS patients from Abidjan (Ivory Coast): antifungal susceptibilities and multilocus enzyme electrophoresis analysis of Candida albicans isolates.

Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used to investigate the Candida albicans strain diversity in twenty nine AIDS patients from Abidjan (Ivory Coast). All patients were monitored for a first episode of oropharyngeal candidiasis and were randomly clustered into three groups of therapy: ketoconazole, amphotericin B or nystatin. Oral swabs were collected before every treatment, 14 and 30 days after the initiation of the therapy; a total of 67 isolates were investigated. No resistant or less susceptible isolate to any antifungal agent was found despite the emergence of clinical relapses, mainly for patients treated with nystatin or amphotericin B. The MEE analysis revealed 27 different electrophoretic types (ETs). Genetic distances between ETs were statistically analyzed and represented on a dendrogram. The 27 ETs clustered into three groups; in each group, ETs represented variants of the same strain. A segregation of the C. albicans isolates seemed to be as a function of the serotype.

[Is cytobacteriological examination of sputum necessary for the diagnosis of bronchopulmonary superinfections in Abidjan?]. / L'examen cytobactériologique des expectorations est-il utile pour le diagnostic des surinfections bronchopulmonaires à Abidjan?

About 276 sputums analysed from 1984 to 1989, 61% of them have been positive. Beside the usual germs of the oropharynged flora, 115 bacteria susceptible of being pathogenic have been isolated. The kinds which are frequently found are Klebsiella = 31 (27%), Escherichia coli = 20 (17%), Enterobacter = 19 (17%), Staphylococcus aureus = 17 (15%) and Pseudomonas aeruginosa = 12 (10%).

[Genital carriage of Streptococcus group B in the pregnant woman in Abidjan (Ivory Coast)]. / Portage génital du streptocoque du groupe B chez la femme enceinte a Abidjan (Cote-d'Ivoire).

To determine the prevalence of group B streptococci to the pregnant woman in Abidjan, we have proceeded an inquiry to a carrier regrouping 150 women examined during a systematic prenatal consultation. The pregnant women did not present any clinical symptoms which can evoke a genital infection. The sampling to the research of group B streptococci have been made to the level of vulva, vagina and cervix. The global frequency of isolation to the pregnant woman is of 19.33% with a frequency of 9.33% to the level of the cervix and the vagina and of 11.33% to the level of the vulva.