RESUMO
The examination of 95 Uzbeks with rheumatic myocardium and 60 healthy subjects of the same nationality has found accumulation in the patients' phenotypes of antigens HLA-B17, HLA-B21 and HLA-Cw4. A high PHA-induced response of T-lymphocytes occurred in HLA-Cw4- and especially in HLA-B21-positive patients. The findings suggest participation of HLA-associated genes in the mechanisms of rheumatic process. These are thought responsible for rheumatism-specific cell immune reactions.
Assuntos
Antígenos HLA/sangue , Cardiopatia Reumática/imunologia , Adolescente , Adulto , Antígenos HLA/genética , Humanos , Células Matadoras Naturais/imunologia , Pessoa de Meia-Idade , Fenótipo , Cardiopatia Reumática/etnologia , Cardiopatia Reumática/etiologia , Cardiopatia Reumática/genética , Linfócitos T/imunologia , UzbequistãoRESUMO
As many as 131 healthy persons (donors) and 83 patients suffering from chronic bronchitis, belonging to the Uzbek nationality were examined. It has been established that there are HLA genetic markers of predisposition and resistance to the development of chronic bronchopulmonary pathology in the population under study. The HLA phenotypic features of patients suffering from chronic bronchitis were reflected in the clinical manifestation of the broncho-obstructive syndrome and at the age of the disease debut. One of the mechanisms of the induction of the bronchopulmonary process in the Uzbek population was revealed by means of simulating the functioning of certain subpopulations of immunocompetent cells.
Assuntos
Bronquite/imunologia , Antígenos HLA/genética , Tolerância Imunológica/imunologia , Linfócitos/imunologia , Adulto , Bronquite/genética , Doença Crônica , Suscetibilidade a Doenças , Marcadores Genéticos/imunologia , Humanos , Tolerância Imunológica/genética , Imunidade Inata/imunologia , Imunofenotipagem , Pessoa de Meia-Idade , Síndrome , UzbequistãoRESUMO
14 Uzbek cousin-marriage families have been immunologically examined. 13 persons have been identified, who are probably homozygous in HLA-D region (the results of the reaction in mixed lymphocyte culture). The members of cousin-marriage families, as compared to healthy Russian donors, had lower proliferative response to phytohemagglutinin and concanavalin A and decreased indexes of concanavalin A-induced suppression and natural killer activity against K562 targets (in children). At the same time natural killer activity in adults, T- and B-lymphocyte content and IgM, IgG and IgA levels are similar to the respective indexes in Russian donors.
