Quality assurance of lead aprons for radiation protection.

Radiation protection is essential to minimize the harmful effects of ionizing radiation. Lead equivalent apron is one of the common protective devices to reduce the occupational risk of radiation exposure. The aim of the study is to analyse the percentage attenuation of 0.5 mm lead equivalent apron. Twenty aprons were used for calculating the percentage of attenuation. The computed tomography (CT) phantom was placed on the radiography and CT table at 1 m from the X-ray tube. The readings were taken from the phantom using a detector at 1-m distance with and without lead equivalent aprons. The readings were tabulated and analysed. The mean percentage attenuation of 0.5 mm lead equivalent apron is 95.66 ± 0.61 in radiography (100 kVp), 95.64 ± 0.57 in CT (130 kVp), respectively. The percentage attenuation of lead equivalent aprons is permissible comparing with the literature.

Targeting Notch signalling pathway of cancer stem cells.

Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies. CSCs have slow growth rate and are resistant to chemotherapy and radiotherapy that lead to the failure of traditional current therapy. Eradicating the CSCs and recurrence, is promising aspect for the cure of cancer. The CSCs like any other stem cells activate the signal transduction pathways that involve the development and tissue homeostasis, which include Notch signaling pathway. The new treatment targets these pathway that control stem-cell replication, survival and differentiation that are under development. Notch inhibitors either single or in combination with chemotherapy drugs have been developed to treat cancer and its recurrence. This approach of targeting signaling pathway of CSCs represents a promising future direction for the therapeutic strategy to cure cancer.