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1.
Ukr Biokhim Zh (1978) ; 62(3): 105-7, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2144380

RESUMO

A change in the regulatory activity of glycolysis enzymes in lymphocytes of the peripheral human blood is studied. The phytohemagglutinin-stimulated lymphocytes differ in the intensification of the glycolysis activation on the whole, as well as in the growth of the cell division intensity under the influence of estradiol 17 beta.


Assuntos
Estradiol/farmacologia , Glicólise/efeitos dos fármacos , Hexoquinase/biossíntese , Linfócitos/enzimologia , Fosfofrutoquinase-1/biossíntese , Piruvato Quinase/biossíntese , Indução Enzimática , Humanos , Técnicas In Vitro , Ativação Linfocitária , Linfócitos/efeitos dos fármacos , Linfócitos/metabolismo
3.
Genetika ; 15(1): 84-8, 1979.
Artigo em Russo | MEDLINE | ID: mdl-118079

RESUMO

The effect of substances with radioprotective activity, APAETP 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), APAETP 3,3 and cystaphos, on chromosome aberrations, induced by thioTEPA in the culture of human lymphocytes was investigated. It is shown that the obtained curves "concentration -- effect" for thioTEPA can be described by equations rho = 1 -- e-(KC + alpha)2 and X = E -(KC + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. On the basis of comparison of angle coefficients of regression the unificated characteristic of the efficiency of chemical mutagenesis is proposed: the linear protection index (LPI), with generalizes the effect of modificators in chemical mutagenesis.


Assuntos
Cromossomos Humanos/efeitos dos fármacos , Mutagênicos/antagonistas & inibidores , Compostos Organotiofosforados/farmacologia , Protetores contra Radiação/farmacologia , Tiotepa/antagonistas & inibidores , Células Cultivadas , Cistafos/farmacologia , Humanos , Linfócitos/efeitos dos fármacos , Matemática , Modelos Biológicos
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