1.
Chem Commun (Camb)
; 59(77): 11564-11567, 2023 Sep 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37682012
RESUMO
We describe herein topological mRNA capture using branched oligodeoxynucleotides (ODNs) with multiple reactive functional groups. These fragmented ODNs efficiently formed topological complexes on template mRNA in vitro. In cell-based experiments targeting AcGFP mRNA, the bifurcated reactive ODNs showed a much larger gene silencing effect than the corresponding natural antisense ODN.