Reaction of alpha,alpha-dibromo oxime ethers with Grignard reagents: alkylative annulation providing a pyrimidine core.

A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines.