RESUMO
In an interview based, case control study of Rheumatoid Arthritis (RA) 168 cases and 137 controls were included. Patients and controls were interviewed with regard to a variety of socioeconomic, medical and dietary factors. During univariate analysis it was found that RA cases consumed significantly less olive oil and fish and adhered more rarely to the dietary restrictions traditional in Orthodox lent than controls. Applying multiple logistic analysis though (by which several variables were controlled for), only the association with olive oil consumption and lent adherence remained significant. More specifically; an increase in olive oil consumption by two times per week, resulted in a Relative Risk (RR) for development of RA of 0.49, whereas adherence to lent during the 27 weeks per year prescribed by the Orthodox Church, resulted in a RR of 0.33. We conclude that olive oil consumption and adherence to Orthodox lent may have a protective effect on the development and/or the severity of RA. This is a hypothesis generated by the present study that needs verification.
Assuntos
Artrite Reumatoide/epidemiologia , Artrite Reumatoide/prevenção & controle , Dieta , Peixes , Óleos de Plantas/farmacologia , Administração Oral , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Artrite Reumatoide/etiologia , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Azeite de Oliva , Óleos de Plantas/administração & dosagem , Fatores de Risco , Fatores SocioeconômicosRESUMO
PIP: A case control study of rheumatoid arthritis and oral contraceptives (OC) or postmenopausal hormones was begun in women aged 20 in 2 hospitals in Athens, with same hospital, age-matched controls. Cases have diagnosed definite or classical rheumatoid arthritis and are being treated in rheumatology clinics. To date 135 cases and 104 controls have been interviewed. 5 cases (3.7%) and 5 controls (4.8% used OCs, with a mean duration of 2 years for both, giving a relative risk of 0.76. 8 more cases and 6 controls were found who used OC for regulation of their menstrual cycle. 1.5% of cases and 3.8% of controls had used post-menopausal hormones. Univariate analysis showed that the cases had later menarche and fewer pregnancies and live births. Multiple regression analysis did not find OC or postmenopausal hormones significantly linked with rheumatoid arthritis. Number of pregnancies and children, however, were significantly higher in controls. Because of the small numbers and low power of the study, more subjects are being collected.^ieng
Assuntos
Artrite Reumatoide/epidemiologia , Anticoncepcionais Orais Hormonais/administração & dosagem , Adulto , Estudos de Casos e Controles , Anticoncepcionais Orais Hormonais/efeitos adversos , Esquema de Medicação , Terapia de Reposição de Estrogênios , Feminino , Grécia/epidemiologia , Humanos , Pessoa de Meia-Idade , Paridade , Gravidez , Análise de RegressãoAssuntos
Imunoglobulina G/análise , Cordão Umbilical , Feminino , Humanos , Recém-Nascido , Ligadura , Gravidez , Fatores de TempoRESUMO
The ability of peripheral blood lymphocytes from polar lepromatous (LL), borderline lepromatous (BL) and borderline tuberculoid (BT) patients to transform in vitro in the presence of phytohemagglutinin was found to be significantly reduced. A significant reduction in the percentage and absolute number of T lymphocytes was observed in LL cases. In BL cases the number of T lymphocytes was decreased, but the reduction was proportional to the reduction in the total lymphocyte population was observed only in bacteriologically positive cases.
