[Investigation of physical activity among adults].

Lack of physical activity as well as smoking, overweight, high blood cholesterol level and hypertension are independent risk factors for development of various chronic diseases. Lack of physical activity is a main cause of non-communicable diseases morbidity and mortality in about 23% of cases (WHO, 2002). Goal of the survey was the identification and characteristics of physical activity among adults. We conducted epidemiologic survey among the school-children and students in Tbilisi. Survey was carried out in 40 schools from all regions of Tbilisi and 9 state and private institutes. Schools were selected by randomized trail in each region of Tbilisi and in each school were questioned all teen-agers from 14-17 year old. For selecting group of survey was used method of "proportional probability of value". There were questioned 2 500 school children and 1000 students, 38% boys and 62% girls. The results of survey ascertained that 23,5%-39,5% of respondents are training or engaged in sport everyday, or several times per week; 17,2% - once in a month; 9,3% once in a year; or 10,5% - never. Adults are less informed about useful effect of physical activity. Respondents had different point of on the role of physical activity: some of them thought it controls weight; others - prevents development of different diseases; the rest thinks that it copes with psycho-emotional stress, and none of them precise about effectiveness of physical activity in all cases mentioned above. Propaganda of healthy life stile must be associated with the effectiveness of physical activity on health.

[Youth health behavior survey].

High-risk behaviours -- smoking, drug use, alcohol use and etc. are the main risk factors of non-communicable diseases and main reasons of morbidity and mortality in many countries of the world. We conducted the "Youth Health Behaviour Survey" among the students in Tbilisi, Mtskheta and Dusheti. The survey included questioning of students (14-17 years old) by modified questionnaire. There were questioned 300 students, 100 in each region. Mtskheta is very close to Tbilisi, it's a peri-urban area; Dusheti is quite far rural area. The survey results show that teenagers both in central and peripheral areas are becoming familiar with alcohol in early ages and using alcohol is several times higher in Tbilisi. In Tbilisi as in Mtskheta and Dusheti students use wine and spirits with same frequency. Smoking is a bit high in Tbilisi and Mtskheta; regular smoking starts at age 13-14, boys are smoking more than girls. Drug use wasn't identified. Sexual intercourse had almost half of boys from Tbilisi and about one third of boys in Mtskheta and Dusheti. Safe sex methods more frequently are used in Tbilisi. Propaganda of healthy life style is essential in supporting healthy youth development. It's very important to set different interventions in different regions of Georgia, to adapt materials to real situation.

[Dipole cooperative model of ion channels of excitable biomembranes. Conductance of ion channels]. / Dipol'naia kooperativnaia model' ionnykh kanalov vozbudimykh biomembran. Provodimost' ionnykh kanalov.

An analysis of ionic channel conductance is presented in terms of dipole cooperative model. The dependence of conductance on displaced charge is found to be an S-shaped function. Basing on this function and kinetics of gating currents, the kinetic curves for the conductance are calculated. These curves are compared with Hodgkin--Huxley results on sodium channel. A good agreement may be observed for the case of positive jumps of the potential. Less accurate coincidence takes place for negative jumps of the potential.

[Dipole cooperative model of ion channels in excitable biomembranes. I. Gating currents]. / Dipol'naia kooperativnaia model' ionnykh kanalov vozbusimykh biomembran. I. Vorotnye toki.

The experimental data on gating currents are analyzed in terms of dipole cooperative model of ionic channel. The dependence of displaced charge on potential is calculated. A comparison between the theory and experiment allows to establish the cooperative part of the charged gating subunits energy. It is shown that kinetics of gating particles displacement is nearly exponential. The theoretical dependence of characteristic times on the potential during testing pulse of voltage agrees qualitatively with the experimental curves.