PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES. / PERSPEKTYVY STVORENNIa ZASOBIV RADIOZAKhYSNOÏ DIÏ NA OSNOVI KOMPOZYTsII PRYRODNYKh POLIFENOL'NYKh SPOLUK I POLISAKhARYDIV.

The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation. Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers. OBJECTIVE: Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides. MATERIAL AND METHODS: The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy. The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated. Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05. RESULTS: The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it. At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals. With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed. At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion. At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds. The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically. CONCLUSIONS: The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.

Analysis of Synergistic Effects of Antimicrobial Peptide Arenicin-1 and Conventional Antibiotics.

We studied combined effects of antimicrobial peptide arenicin-1 from lugworm Arenicola marina and some conventional antibiotics. A number of drug combinations with pronounced synergistic effects were revealed. The influence of antibacterial activity assessment conditions was determined and the methodology excluding false-positive test results was developed.

[Gastroesophageal reflux disease as a surgical problem]. / Gastroézofageal'naia refliuksnaia bolezn' kak khirurgicheskaia problema.

Photodynamical and chromoesophagoscopic diagnostics in recognizing of Barrett disease are described in the article. The indications for surgical treatment of esophagogastric reflux disease are presented.

[Irreversible changes in energy processes in the mitochondria after chronic exposure to detergents]. / Neobratimye izmeneniia énergeticheskikh protsessov v mitokhondriiakh pod vliianiem khronicheskogo vozdeistviia detergenta

Chronic inhalational exposure of white rats to a synthetic detergent 'LOTOS' in concentrations 25 and 100 mg/m3 caused liver mitochondria bioenergetics changes from a reversible low energetic shift up to an irreversible mitochondria damage of an organ-structural character. The degree of the damaging effect depended on the duration of exposure and the concentration of the detergent.

[Changes in total hemodynamics of central genesis following removal of basal meningiomas]. / Izmeneniia obshchei gemodinamiki tsentral'nogo geneza pri udalenii bazal'nykh meningiom

The removal of basal intracranial meningiomas in 54 patients, even under general anesthesia with neuro-autonomous blocking, was accompanied by cardiovascular reactions caused by both reflex effects and direct excitation of brain stem structures. These reactions were always of a pressor nature only. Postoperatively, the vascular reactions were also of a pressor nature and presented themselves as components of either a non-specific stress response or a developing diencephalo-catabolic syndrome. Taking into account that the leading cause of the vascular disorders in stress responses and the diencephalo-catabolic syndrome is the irritative process in the brain stem structures, it is important for the prevention and management of these disorders to suppress by pharmacological means the irritation of the median formations with simultaneous blood replacement and conduction of maintenance cardiac therapy.