1.
Chem Commun (Camb)
; 50(50): 6623-5, 2014 Jun 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24824405
RESUMO
A cis-2-aminomethyl-5-phenylpyrrolidine, which is easily available from methyl Boc-L-pyroglutamate, was found to be a highly efficient chiral ligand for Cu(II)-catalysed Henry reactions. Excellent yields (>90%) and superb levels of enantiocontrol (98.5-99.6% ee) were reached with aromatic, heteroaromatic, vinylic, and aliphatic aldehydes (36 examples).