[Correlation of salivary and genital glands].

Based on the experimental data correlation of parotids and genital glands in 24 male rabbits 1.5 months after testectomy (full testectomy, unilateral partial resection and bilateral partial resection) was found out. The findings included hyperplasia, parenchyma atrophy, stromal and periductal sclerosis of the parotids. In the majority of cases in adjacent lymphatic notes hyperplasia of B-zones and devastation of T-zones may also be seen, confirming autoimmune reaction after genital glands injury.

[Sexual dysfunction in Russia: risk factors for women].

The aim of the study was to identify the most important risk factors in genesis of female sexual dysfunction (FSD) using a Russian modification of the female sexual function index (FSFI) questionnaires and original questionnaires for Russian women. A total of 540 women aged 18-75 years living in the South of Russia entered the trial. They were divided into 4 groups: group 1--18-30 year old women (n = 250), group 2--premenopausal women (n = 213), group 3--women with 5 year and less menopause (n = 39), group 4--women with 5 year and longer menopause. Age, stress and menopause were identified to be significant risk factors of FSD. The other factors were not significant. A mathematical model was designed and the coefficient of each risk factor was estimated for determination of individual probability to develop FSD in Russian women.

[Efficacy and safety of hormonal therapy with androgens (androgel) in men with erectile dysfunction, partial androgen deficiency of aging male and cardiovascular diseases].

Partial androgen deficiency of aging male (PADAM) manifests with sexual dysfunction and is associated with many diseases, primarily, cardiovascular. After the age of 30-40 a testosterone level falls 1-2% a year. The number of men with testosterone deficiency grows from 8% in 40-60-year-olds to 85% at the age over 80 years. Low testosterone correlates with such risk factors of cardiovascular diseases as dyslipidemia, atherosclerosis, low fibrinolysis, insulin resistance and abdominal obesity. Correction of androgenic deficiency can be conducted with the drug androgel which represents a new system of transdermal testosterone delivery. In contrast to vasoactive drugs, androgel affects pathogenetic mechanisms of erectile dysfunction and thus attenuates factors of cardiovascular risk. Androgel is used externally and is more effective than intramuscular and oral analogues. Also, the drug improves lipid spectrum. By activating lipolysis, testosterone reduces the amount of visceral fat thus lowering insulin resistance. A vasodilating effect of androgel positively influences cardiovascular system and penile vessels. The drug acts fast, is effective and safe. Therefore, it can be recommended for correction of erectile dysfunction in patients with old age androgen deficiency and concurrent cardiovascular diseases.

[Partial androgen deficiency in aging male (Padam syndrome): terminology and current approaches to choice of replacement hormonal therapy].

The authors propose a novel approach to treatment of PADAM syndrome based on stimulation of synthesis of endogenic testosterone. A total of 150 patients with PADAM were examined in the Endocrinological Research Center. The examination included physical and andrological examinations with digital rectal investigation of the prostate, filling-in questionnaires, hormonal and biochemical tests. In view of positive test with chorionic gonadotropin (CG), therapy of choice was stimulating therapy with CG. The dose was adjusted individually - from 1000 to 3000 units once in 4 days (1000 units dose was given to 20% patients, 2000 - to 70% and 3000 - to 10% patients). Efficacy did not reduce in long-term treatment. The authors make the following conclusion: choice of PADAM therapy should be individual and based on the age of the patient, body mass index, the necessity to retain spermatogenesis, packed cell volume, associated diseases. Secondary nature of PADAM and positive test for CG allows usage of CG as a perspective therapy in prevention and treatment of age-related lowering of testosterone.

[Spermatogenesis disorders in transsexual patients]. / Narusheniia spermatogeneza u bol'nykh transseksualizmom.

Examinations of the semen in 8 patients with male transsexualism revealed stereotypical changes in spermograms ranging from oligo- to azoospermia. Possible mechanisms responsible for this abnormality are discussed.