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Environ Toxicol Pharmacol ; 104: 104283, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37775076

RESUMO

Retained lead fragments from nonfatal firearm injuries pose a risk of lead poisoning. While chelation is well-established as a lead poisoning treatment, it remains unclear whether chelation mobilizes lead from embedded lead fragments. Here, we tested whether 1) DMSA/succimer or CaNa2EDTA increases mobilization of lead from fragments in vitro, and 2) succimer is efficacious in chelating fragment lead in vivo, using stable lead isotope tracer methods in a rodent model of embedded fragments. DMSA was > 10-times more effective than CaNa2EDTA in mobilizing fragment lead in vitro. In the rodent model, succimer chelation on day 1 produced the greatest blood lead reductions, and fragment lead was not mobilized into blood. However, with continued chelation and over 3-weeks post-chelation, blood lead levels rebounded with mobilization of lead from the fragments. These findings suggest prolonged chelation will increase fragment lead mobilization post-chelation, supporting the need for long-term surveillance in patients with retained fragments.


Assuntos
Armas de Fogo , Intoxicação por Chumbo , Ferimentos por Arma de Fogo , Animais , Humanos , Succímero , Chumbo/toxicidade , Ácido Edético/farmacologia , Ácido Edético/uso terapêutico , Roedores , Quelantes/farmacologia , Quelantes/uso terapêutico , Intoxicação por Chumbo/tratamento farmacológico , Intoxicação por Chumbo/metabolismo
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