RESUMO
The methods of light microscopy, immunohistochemistry, and electron microscopy were employed to study the morphofunctional changes in epithelium of bronchial and respiratory segments of the rat lungs used as models of acute fatal poisoning with household gas. It was shown that this toxic effect induces the pathological process involving all the elements of the epithelial layer in the bronchial and respiratory segments of the lungs of experimental animals. At the ultrastructural level, mitochondria and endoplasmic reticulum structures are affected, with the death of epithelial cells leading to the damage of the aerohematic barrier. The toxic effect of the gaseous mixture on the membranes causes the destruction of various elements of the epithelial layer. The results of this study help to understand the mechanisms of death in the case of acute fatal poisoning with household gas.
Assuntos
Modelos Animais de Doenças , Pulmão/ultraestrutura , Gás Natural/intoxicação , Doença Aguda , Animais , Morte Celular , Retículo Endoplasmático/efeitos dos fármacos , Retículo Endoplasmático/ultraestrutura , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/ultraestrutura , Pulmão/efeitos dos fármacos , Masculino , Microscopia Eletrônica , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/ultraestrutura , Intoxicação/etiologia , Intoxicação/patologia , Ratos , Ratos WistarRESUMO
The genetic control of the traits "plant height", "the number of lateral shoots" and "the number of lateral stems" has been studied in 3 pure lines and 1 variety of linseed according to the model 1 of Hayman method. It has been shown that the traits under investigation are inherited according to the additive-dominant model of genetic control in the absence of any interloci interactions. The higher plant height and numerous lateral shoots are recessive traits controlled by 2 blocks of polymeric genes, whereas the trait of numerous lateral stems is a dominant trait influenced by 1 to 3 blocks of genes. The linseed lines have been ranked according to the number of dominant alleles they have. Suggestions for selection using these parental genotypes have been made.
Assuntos
Linho/crescimento & desenvolvimento , Linho/genética , Locos de Características Quantitativas/genética , Característica Quantitativa Herdável , Alelos , Cruzamentos Genéticos , Genes Dominantes , Modelos GenéticosAssuntos
Neoplasias do Colo/mortalidade , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Colo/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Federação Russa/epidemiologia , Distribuição por Sexo , Análise de Sobrevida , Adulto JovemRESUMO
A 45 year-old woman presented with late-diagnosed celiac disease, marked disorders of calcium and bone metabolism, and severe osteoporosis. Weak enteral symptoms delayed diagnosis. High efficiency of agluten and vitamin D therapy was documented.
Assuntos
Doença Celíaca/diagnóstico , Duodeno/patologia , Endoscopia Gastrointestinal/métodos , Biópsia , Conservadores da Densidade Óssea/uso terapêutico , Doença Celíaca/complicações , Doença Celíaca/terapia , Diagnóstico Tardio , Diagnóstico Diferencial , Dieta Livre de Glúten , Feminino , Humanos , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Osteoporose/etiologia , Vitamina D/uso terapêuticoRESUMO
A morphologic and morphometric study of duodenal mucosal biopsies obtained from 90 patients suffering of celiac sprue was done. The results were compared with clinical, serological features as well as with information on inheritance. The diagnosis of celiac sprue was made when there was a combination of both specific clinical and serological signs with chronic atrophic mucosal changes in the duodenum correlating with morphometrical data. It was concluded that the lack of one of the mentioned parameters makes the diagnosis invalid and the patient needs further observation.
