[The influence of amlodipine on transcapillary metabolism of oxygen during coronary heart disease with insulin resistance].

This three-week open uncontrolled study included 34 men (mean age 53.14+-1.19 yr) with coronary heart disease (CHD) and insulin resistance (HOMA >2. 77); it was designed to estimate effect of amlodipine on transcapillary oxygen metabolism (TCOM). Multivascular stenosing coronary atherosclerosis was managed by aortocoronary bypass surgery. Traditional methods applied in specialized cardiological clinics were supplemented by TCOM measurement using a PA-2 polarograph (Czech Rep.). Polarography revealed deterioration of TCOM parameters including permeability of hemocapillaries, adaptive reserves of the microcirculatory bed, and oxygen supply to the tissues. Amlodipine therapy demonstrated high antianginal potency of this drug and its ability to improve TCOM

[Clinical and functional changes in the biliary tract in patients with psoriasis concurrent with chronic opisthorchiasis].

OBJECTIVE: to study the clinical and functional changes in the biliary tract in patents with psoriasis concurrent with chronic opisthorchiasis (CO). SUBJECTS AND METHODS: 60 patients with psoriasis concurrent with CO, 45 patients with psoriasis without helminthism, 30 with CO, and 15 healthy individuals were examined. Chromatic fractional duodenal intubation, dynamic hepatobiliscintigraphy, and ultrasound study of the liver and gallbladder were used. The concentrations of cholesterol, bile acids, bilirubin, total lipids and phospholipids in bile were measured. A number of relative indices, such as cholate-cholesterol coefficient (CCC), Thomas-Hofmann index, and Rubens index were calculated. RESULTS AND DISCUSSION: The patients with psoriasis with CO were found to have signs of mainly hypermotor dyskinesia of the biliary tract, as well as increased bile lithogenicity (lower CCC, and increases in the Rubens index and Thomas-Hofmann index). CONCLUSIONS: The clinical and functional changes found in the biliary tract of the patients with psoriasis concurrent with CO show it necessary to perform antihelminthic therapy in this group of patients.

[Impact of dehelminthization on pancreatic incretory and excretory functions in patients with psoriasis concurrent with chronic opisthorchiasis].

A hundred and thirty patients, including 60 patients with psoriasis concurrent with chronic opisthorchiasis, 40 with psoriasis without helminthiasis, and 30 with chronic opisthorchiasis, and 15 healthy individuals were examined. To evaluate the pancreas, its incretory and excretory functions were studied. In patients with psoriasis concurrent with chronic opisthorchiasis, the pancreatic level of hormones and enzymes was significantly lower than those in patients with psoriasis without helminthiasis. Twelve months after dehelminthization, a follow-up of the parameters of the incretory function revealed their significant increase in 43 patients. Following dehelminthization, the excretory function in terms of amylase and lipase was significantly greater than that before dehelminthization. By taking into account steatorrhea, pancreatic excretory dysfunction showed significantly less fecal fat losses after a course of anthelminthic therapy. Malabsorption diminished in patients after anthelminthic therapy, as confirmed by increased urinary D-xylose excretion. Pancreatic proteolytic activity improved after dehelminthization, as supported by a significant increase in urinary PABA excretion. No improvement was observed in patients receiving no anthelminthic therapy; on the contrary, deterioration was established in half of them. Therefore, a year after dehelminthization, helminthological cure in patients with psoriasis concurrent with chronic opisthorchiasis causes a significant improvement in pancreatic incretory and excretory functions and promotes regression of psoriatic manifestation.

[Disturbances of the incretory and excretory pancreatic functions in patients suffering from psoriasis in combination with chronic opisthorchosis].

The aim of the study was to evaluate the incretory and excretory functions of the pancreas in patients suffering from psoriasis in combination with chronic opisthorchosis (CO). The subjects were 30 patients with psoriasis and CO, 20 patients with psoriasis without helminthiasis, 20 patients with CO, and 12 healthy individuals. The incretory pancreatic function was studied by measuring serum levels of pancreatic hormones (insulin, glucagon, and C-peptide) using radioimmunoassay with standard sets; the excretory function was studied by means of measuring serum levels of pancreatic enzymes (amylase and lipase) using a biochemical technique. Proteolytic capacity was evaluated using PABA test (per cent of the renal excretion of paraminobenzoic acid); amylolytic capacity was evaluated using coprogram results. The study revealed disturbances in the incretory and excretory functions of the pancreas in patients suffering from psoriasis or psoriasis with CO. The latter subgroup had more prominent disturbances.

[The clinical and functional status of the pancreas in patients with psoriasis concurrent with chronic opisthorchiasis].

Seventy patents including 30 with psoriasis concurrent with chronic opisthorchiasis, 20 with psoriasis without opisthorchiasis, and 20 with chronic opisthorchiasis, were examined. Structural changes in the pancreas and its endocrine and exocrine functions were evaluated. Patients with psoriasis alone or in combination with chronic opisthorchiasis were found to have signs of pancreatic lesion with its impaired endocrine and exocrine functions. These impairments are more pronounced in the group of patients with mixed pathology.

[Kidney involvement in trophoblastic disease (chorionepithelioma)]. / Porazhenie pochek pri trofoblasticheskoi bolezni (khorionepiteliome).

Renal involvement in chorionepithelioma is attributed to tumor destruction and metastases to the kidneys. A rare case of secondary paraneoplastic nephropathy manifesting as nephrotic syndrome in the presence of renal metastases is described. Metastatic lesion of the lungs provoked spontaneous pneumothorax. It is not easy to detect chorionepithelioma and related paraneoplastic nephropathy. Therefore, special attention should be given to puerperants with unusual clinical presentation of nephrotic syndrome, with bloody expectorations. In the above cases chorionepithelioma must not be excluded.

[The effect of specific treatment on the function of the small intestine in opisthorchiasis]. / Vliianie spetsificheskogo lecheniia na funktsional'noe sostoianie tonkoi kishki pri opistorkhoze.

The anthelminthic agents chloxylum and prasiquantel were examined for their effects in patients with an above 5-year history of Opisthorchis invasion. The van de Kamer procedure revealed that chloxylum produced an inhibitory effect on absorption of d-xylose and fat. Prasiquantel failed to impair the absorptive function of the small intestine. Helminthological curing in patients with chronic opisthorchiasis was not shown to normalize dysfunction of the small intestine.

[Clinico-functional status of the small intestine in patients with chronic opisthorchiasis]. / Kliniko-funktsional'noe sostoianie tonkoi kishki u bol'nykh khronicheskim opistorkhozom.

Examination of 110 patients with chronic opisthorchiasis lasting for over 5 years has revealed the syndrome of malabsorption by means of the d-xylose test, Kamer's method and radioindication. Dysbacteriosis, hypokinesia of the small intestine, reduction of the cholate-cholesterol ratio of the bile, structural alterations in the small intestine mucosa were found to be implicated in the genesis of malabsorption. The helminthologic recovery of the patients with protracted opisthorchiasis did not entail complete normalization of the function of the small intestine and thus required therapeutic correction.